PMID- 9860004
OWN - NLM
STAT- MEDLINE
DCOM- 19981228
LR  - 20190627
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 126
IP  - 6
DP  - 1998 Dec
TI  - Human leukocyte antigens associated with hyperthyroid Graves ophthalmology in 
      Japanese patients.
PG  - 805-10
AB  - PURPOSE: To evaluate the association of human leukocyte antigen (HLA) types in 
      Japanese patients with Graves ophthalmopathy. METHODS: Japanese patients with 
      severe ophthalmopathy (48 patients) and patients without ophthalmopathy (46 
      patients) were selected prospectively from 234 consecutive patients with 
      hyperthyroid Graves disease. The criteria for severe ophthalmopathy were 
      proptosis of 19 mm or more, or a 3-mm difference in exophthalmometry measurement 
      between the two eyes, or diplopia at the primary eye position. The criteria for 
      the absence of ophthalmopathy were proptosis of 16 mm or less, no diplopia, no 
      lid retraction, and no thickening of extraocular muscles. Serologic HLA typing of 
      class I and II antigens was performed in the two patient groups. The frequency of 
      each HLA antigen in the two patient groups was compared to that in 767 unrelated 
      normal healthy Japanese controls. RESULTS: The frequencies of HLA-DR14 and DQ1 
      were significantly higher in the patient group with severe ophthalmopathy (35% 
      and 75%, respectively) than in healthy controls (4% and 43%, respectively; 
      corrected P < .05), and also greater than in the patient group without 
      ophthalmopathy (13% and 55%, respectively; P < .01). On the other hand, the 
      frequencies of HLA-B35, B54, DR4, and DQ4 were significantly higher in the 
      patient group without ophthalmopathy (23%, 23%, 43%, and 30%, respectively) than 
      in the patient group with severe ophthalmopathy (13%, 15%, 25%, and 19%, 
      respectively; P < .01). CONCLUSIONS: HLA-DR14 and DQ1 antigens may be genetic 
      markers of predisposition to the development of severe ophthalmopathy. In 
      addition, HLA-B35, B54, DR4, and DQ4 may be genetic markers of resistance to 
      severe ophthalmopathy. Variation in the severity of ophthalmopathy associated 
      with Graves disease may depend, in part, on the presence or absence of particular 
      HLA antigens.
FAU - Ohtsuka, K
AU  - Ohtsuka K
AD  - Department of Ophthalmology, Sapporo Medical University, School of Medicine, 
      Hokkaido, Japan.
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Genetic Markers)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class I/genetics
MH  - Genes, MHC Class II/genetics
MH  - Genetic Markers
MH  - Graves Disease/*blood/genetics
MH  - Histocompatibility Antigens Class I/*blood/genetics
MH  - Histocompatibility Antigens Class II/*blood/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 1998/12/22 00:00
MHDA- 1998/12/22 00:01
CRDT- 1998/12/22 00:00
PHST- 1998/12/22 00:00 [pubmed]
PHST- 1998/12/22 00:01 [medline]
PHST- 1998/12/22 00:00 [entrez]
AID - S0002939498002487 [pii]
AID - 10.1016/s0002-9394(98)00248-7 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 1998 Dec;126(6):805-10. doi: 10.1016/s0002-9394(98)00248-7.