PMID- 9861627
OWN - NLM
STAT- MEDLINE
DCOM- 19990224
LR  - 20131121
IS  - 1230-6002 (Print)
IS  - 1230-6002 (Linking)
VI  - 50
IP  - 3
DP  - 1998 May-Jun
TI  - Effect of nifedipine and verapamil on hypotensive action of clonidine in rabbits.
PG  - 193-201
AB  - The present study examined the influence of nifedipine and verapamil on 
      clonidine-induced hypotension in the rabbits. Clonidine was given intravenously 
      (i.v.) (0.2 mg/kg) or intracerebroventricularly (icv) (0.03 mg). Nifedipine (0.3 
      mg/kg and 0.45 mg/kg) and verapamil (0.2 mg/kg and 0.3 mg/kg) were injected i.v. 
      15 min before clonidine administration or icv (nifedipine 0.03 mg, verapamil 0.1 
      mg) 10 min before clonidine. It has been shown that nifedipine administered i.v. 
      increases whereas injected icv prevents the hypotensive action of clonidine 
      administered in the same way. Verapamil injected i.v. and icv did not change the 
      hypotensive action of clonidine. It seems that nifedipine has alpha 
      2-adrenoceptor blocking properties.
FAU - Czarnecka, E
AU  - Czarnecka E
AD  - Department of Pharmacology, Medical University of Lodz, Poland.
FAU - Tymczyszyn, W
AU  - Tymczyszyn W
FAU - Pietrzak, B
AU  - Pietrzak B
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Pol J Pharmacol
JT  - Polish journal of pharmacology
JID - 9313882
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Calcium Channel Blockers)
RN  - CJ0O37KU29 (Verapamil)
RN  - I9ZF7L6G2L (Nifedipine)
RN  - MN3L5RMN02 (Clonidine)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/*pharmacology
MH  - Blood Pressure/drug effects
MH  - Calcium Channel Blockers/*pharmacology
MH  - Clonidine/*pharmacology
MH  - Drug Interactions
MH  - Female
MH  - Heart Rate/drug effects
MH  - Male
MH  - Nifedipine/*pharmacology
MH  - Rabbits
MH  - Time Factors
MH  - Verapamil/*pharmacology
EDAT- 1998/12/23 00:00
MHDA- 1998/12/23 00:01
CRDT- 1998/12/23 00:00
PHST- 1998/12/23 00:00 [pubmed]
PHST- 1998/12/23 00:01 [medline]
PHST- 1998/12/23 00:00 [entrez]
PST - ppublish
SO  - Pol J Pharmacol. 1998 May-Jun;50(3):193-201.