PMID- 9862231
OWN - NLM
STAT- MEDLINE
DCOM- 19990322
LR  - 20190831
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 105
IP  - 3
DP  - 1998 Nov 16
TI  - Modification of HLA expression on peripheral lymphocytes and monocytes during 
      aging.
PG  - 209-20
AB  - Immunosenescence involves modifications of humoral and cellular immunity. Here we 
      report the analysis of human leukocyte antigen (HLA) expression on T lymphocytes, 
      B lymphocytes and monocytes of 58 healthy subjects aged 23-95 years old. Using a 
      double staining immunofluorescence and flow cytometry analysis, we have 
      determined the percentages of cells expressing HLA class-I and HLA-DR antigens. 
      The number of antigenic sites expressed per cell were evaluated for HLA-ABCw, 
      HLA-A, HLA-B, HLA-DR locus with a flow cytometry quantification technique. With 
      advancing age, we observed: (i) a significant decrease of the percentage of T 
      cells and B cells expressing HLA-A products; (ii) a decrease of the number of HLA 
      class-I antigenic sites expressed per cell on the three populations tested, 
      predominantly on B cells and in a locus-dependent fashion; (iii) a decrease of 
      the number of HLA-DR molecules expressed per T cell, although the percentage of T 
      cells expressing DR products was increased; (iv) a significant diminution of the 
      percentage of B cells expressing HLA-DR molecules, without changes of the number 
      of HLA-DR antigenic sites per cells. These changes in HLA expression with 
      increasing age could contribute to the decreased level of immunologic 
      responsiveness observed with ageing and contribute to the modification of antigen 
      recognition.
FAU - Le Morvan, C
AU  - Le Morvan C
AD  - Laboratoire d'Immunologie et Immunogenetique CNRS EP118, Faculte de Medecine, 
      Limoges, France.
FAU - Cogne, M
AU  - Cogne M
FAU - Troutaud, D
AU  - Troutaud D
FAU - Charmes, J P
AU  - Charmes JP
FAU - Sauvage, P
AU  - Sauvage P
FAU - Drouet, M
AU  - Drouet M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*immunology
MH  - B-Lymphocytes/immunology
MH  - Female
MH  - HLA-DR Antigens/*biosynthesis/immunology
MH  - Histocompatibility Antigens Class I/*biosynthesis/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monocytes/immunology
MH  - T-Lymphocytes/immunology
EDAT- 1998/12/23 00:00
MHDA- 1998/12/23 00:01
CRDT- 1998/12/23 00:00
PHST- 1998/12/23 00:00 [pubmed]
PHST- 1998/12/23 00:01 [medline]
PHST- 1998/12/23 00:00 [entrez]
AID - S0047637498000967 [pii]
AID - 10.1016/s0047-6374(98)00096-7 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 1998 Nov 16;105(3):209-20. doi: 10.1016/s0047-6374(98)00096-7.