PMID- 9863527
OWN - NLM
STAT- MEDLINE
DCOM- 19990302
LR  - 20190815
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 19
IP  - 21
DP  - 1998 Nov
TI  - Hydroxyapatite fiber reinforced poly(alpha-hydroxy ester) foams for bone 
      regeneration.
PG  - 1935-43
AB  - A process has been developed to manufacture biodegradable composite foams of 
      poly(DL-lactic-co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use 
      in bone regeneration. The processing technique allows the manufacture of 
      three-dimensional foam scaffolds and involves the formation of a composite 
      material consisting of a porogen material (either gelatin microspheres or salt 
      particles) and hydroxyapatite short fibers embedded in a PLGA matrix. After the 
      porogen is leached out, an open-cell composite foam remains which has a pore size 
      and morphology defined by the porogen. By changing the weight fraction of the 
      leachable component it was possible to produce composite foams with controlled 
      porosities ranging from 0.47 +/- 0.02 to 0.85 +/- 0.01 (n = 3). Up to a 
      polymer:fiber ratio of 7:6, short hydroxyapatite fibers served to reinforce 
      low-porosity PLGA foams manufactured using gelatin microspheres as a porogen. 
      Foams with a compressive yield strength up to 2.82 +/- 0.63 MPa (n = 3) and a 
      porosity of 0.47 +/- 0.02 (n = 3) were manufactured using a polymer:fiber weight 
      ratio of 7:6. In contrast, high-porosity composite foams (up to 0.81 +/- 0.02, n 
      = 3) suitable for cell seeding were not reinforced by the introduction of 
      increasing quantities of hydroxyapatite short fibers. We were therefore able to 
      manufacture high-porosity foams which may be seeded with cells but which have 
      minimal compressive yield strength, or low porosity foams with enhanced 
      osteoconductivity and compressive yield strength.
FAU - Thomson, R C
AU  - Thomson RC
AD  - Institute of Biosciences and Bioengineering and Department of Chemical 
      Engineering, Rice University, Houston, TX 77005-1892, USA.
FAU - Yaszemski, M J
AU  - Yaszemski MJ
FAU - Powers, J M
AU  - Powers JM
FAU - Mikos, A G
AU  - Mikos AG
LA  - eng
GR  - R29-AR42639/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - *Bone Regeneration
MH  - Compressive Strength
MH  - Durapatite/*chemistry
MH  - Guided Tissue Regeneration/*methods
MH  - Lactic Acid/chemistry
MH  - Polyesters/*chemistry
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemistry
MH  - Porosity
OTO - NASA
OT  - NASA Discipline Cell Biology
OT  - Non-NASA Center
FIR - McIntire, L V
IR  - McIntire LV
IRAD- Rice U, Houston, TX
EDAT- 1998/12/24 00:00
MHDA- 1998/12/24 00:01
CRDT- 1998/12/24 00:00
PHST- 1998/12/24 00:00 [pubmed]
PHST- 1998/12/24 00:01 [medline]
PHST- 1998/12/24 00:00 [entrez]
AID - S0142-9612(98)00097-0 [pii]
AID - 10.1016/s0142-9612(98)00097-0 [doi]
PST - ppublish
SO  - Biomaterials. 1998 Nov;19(21):1935-43. doi: 10.1016/s0142-9612(98)00097-0.