PMID- 9863999
OWN - NLM
STAT- MEDLINE
DCOM- 19990323
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 12
IP  - 5
DP  - 1998 Nov
TI  - Rhinitis alone or rhinitis plus asthma: what makes the difference?
PG  - 1073-8
AB  - This paper examines the clinical expression of asthma in a group of patients 
      displaying rhinitis according to age, sex, associated symptoms, smoking, familial 
      history of asthma, atopy, type of sensitization to aeroallergens (pollens and/or 
      indoor allergens), total serum immunoglobulin E (IgE), and blood eosinophils. A 
      total of 117 adults with rhinitis were analysed on the basis of symptoms. Among 
      them, 51 also displayed asthma, defined as a history of recurrent episodes of 
      dyspnoea with a reversible airflow obstruction or a positive methacholine 
      challenge. The logistic regression analysis carried out in a stepwise approach, 
      combining several factors, showed that various parameters affected the risk of 
      having asthma associated with rhinitis. A further analysis was made in 74 
      rhinitis patients comparing 42 subjects without nonallergic airway 
      hyperresponsiveness (NAAH) to 32 patients with asthma and NAAH. Atopy, high total 
      serum IgE levels, elevated blood eosinophil count and maternal asthma were 
      associated with asthma. Furthermore, in atopic patients, pollen sensitization was 
      more closely related to rhinitis alone, whereas sensitization to indoor allergens 
      was a major determinant for the association of asthma with the symptoms of 
      rhinitis. The same risk factors as those found in the clinical part of the study 
      discriminated the patients with rhinitis without NAAH from those with rhinitis, 
      asthma and NAAH. In conclusion, this study gives new insights into the 
      relationships between asthma and rhinitis.
FAU - Magnan, A
AU  - Magnan A
AD  - UPRES No. 2050, Dept of Chest Diseases, Hopital Sainte Marguerite, Marseilles, 
      France.
FAU - Fourre-Jullian, C
AU  - Fourre-Jullian C
FAU - Jullian, H
AU  - Jullian H
FAU - Badier, M
AU  - Badier M
FAU - Lanteaume, A
AU  - Lanteaume A
FAU - Vervloet, D
AU  - Vervloet D
FAU - Charpin, D
AU  - Charpin D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/*complications/diagnosis
MH  - Bronchial Hyperreactivity/complications
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/complications/diagnosis
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Prospective Studies
MH  - Rhinitis, Allergic, Perennial/*complications
MH  - Rhinitis, Allergic, Seasonal/*complications/diagnosis
EDAT- 1998/12/24 00:00
MHDA- 1998/12/24 00:01
CRDT- 1998/12/24 00:00
PHST- 1998/12/24 00:00 [pubmed]
PHST- 1998/12/24 00:01 [medline]
PHST- 1998/12/24 00:00 [entrez]
AID - 10.1183/09031936.98.12051073 [doi]
PST - ppublish
SO  - Eur Respir J. 1998 Nov;12(5):1073-8. doi: 10.1183/09031936.98.12051073.