PMID- 9864034
OWN - NLM
STAT- MEDLINE
DCOM- 19990317
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 52
IP  - 5
DP  - 1998 Nov
TI  - HLA class I and class II of the Nivkhi, an indigenous population carrying HTLV-I 
      in Sakhalin, Far Eastern Russia.
PG  - 444-51
AB  - The Nivkhi are a native people isolated in the Nogliki region of Sakhalin, Far 
      East Russia, where our group recently recognized human T-cell lymphoma virus type 
      I (HTLV-I) infection. In order to trace the Nivkhi's ethnic background and the 
      HTLV-I carriers, we investigated HLA class I and II allele types of 53 Nivkhi 
      (including four HTLV-I carriers). Major HLA class I alleles of the Nivkhi were 
      A*24, A*02, B*40, B*48, B*27, B*35 with allele frequencies similar to the 
      Orochon, a native people isolated in Northeast China. Major Nivkhi class II 
      alleles were DRB1*0901, DRB1*1401, DRB1*1201, DRB1*1106 with allele frequencies 
      similar to the Ainu in Hokkaido, Japan, but dissimilar to other Asian Mongoloids, 
      including the general Japanese population. The same HLA class I and II allele 
      frequencies are found in both Nivkhi HTLV-I carriers and the background 
      population. A dendrogram of HLA class I alleles showed that the Nivkhi were 
      closely related to the Orochon and Yakut, and remotely related to the Japanese, 
      Ainu and other Asian Mongoloids. Interestingly, the Nivkhi were intermediately 
      related to the Amerindians (Inuit, Tlingit and Andeans), a relationship closer 
      than to the Japanese and Asian Mongoloids. These results suggested the Nivkhi 
      might be related to some genetic group of Northeast Asian Mongoloids like the 
      Orochon and Yakut, being infected with HTLV-I in the distant past before 
      diverging into the current major Mongoloid ethnic groups.
FAU - Lou, H
AU  - Lou H
AD  - Department of Virology, Faculty of Medicine, Kagoshima University, Sakuragaoka, 
      Japan.
FAU - Li, H C
AU  - Li HC
FAU - Kuwayama, M
AU  - Kuwayama M
FAU - Yashiki, S
AU  - Yashiki S
FAU - Fujiyoshi, T
AU  - Fujiyoshi T
FAU - Suehara, M
AU  - Suehara M
FAU - Osame, M
AU  - Osame M
FAU - Yamashita, M
AU  - Yamashita M
FAU - Hayami, M
AU  - Hayami M
FAU - Gurtsevich, V
AU  - Gurtsevich V
FAU - Ballas, M
AU  - Ballas M
FAU - Imanishi, T
AU  - Imanishi T
FAU - Sonoda, S
AU  - Sonoda S
LA  - eng
SI  - GENBANK/AB010269
SI  - GENBANK/AB010270
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asia
MH  - Asian People/genetics
MH  - Base Sequence
MH  - Ethnicity/*genetics
MH  - Female
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - *Human T-lymphotropic virus 1
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - North America
MH  - Russia
MH  - South America
EDAT- 1998/12/24 00:00
MHDA- 1998/12/24 00:01
CRDT- 1998/12/24 00:00
PHST- 1998/12/24 00:00 [pubmed]
PHST- 1998/12/24 00:01 [medline]
PHST- 1998/12/24 00:00 [entrez]
AID - 10.1111/j.1399-0039.1998.tb03071.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1998 Nov;52(5):444-51. doi: 10.1111/j.1399-0039.1998.tb03071.x.