PMID- 9864402
OWN - NLM
STAT- MEDLINE
DCOM- 19990322
LR  - 20190516
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 6
IP  - 1
DP  - 1999 Jan-Feb
TI  - Increased chromosome exchange frequencies in iodo-deoxyuridine-sensitized human 
      SW-1573 cells after gamma-irradiation.
PG  - 59-63
AB  - The induction of chromosome exchanges was investigated in SW-1573 human lung 
      tumour cells radiosensitized with iododeoxyuridine (IdUrd) and irradiated with 
      gamma-rays. Following treatment chromosome 2 and X were analyzed using 
      fluorescence in situ hybridization (FISH) with chromosome-specific DNA libraries. 
      The yield of chromosome exchanges involving chromosome 2 was higher than those 
      involving chromosome-X. On the basis of the DNA content the relative involvement 
      of the X-chromosome in exchange frequencies after 2 Gy was much higher than of 
      chromosome 2. After 4 Gy the relative involvement of both chromosomes in 
      exchanges is approximately equal. After radiosensitization, increased chromosome 
      exchange frequencies are observed in both studied chromosomes. For the total 
      chromosome exchange frequencies the sensitizer enhancement ratio (SER) at 2 Gy is 
      1.8 and 1.3 for chromosome 2 and X respectively. The SER at 4 Gy for total 
      exchange frequencies is 1.6 and 1.9 chromosome 2 and X respectively. For 
      reciprocal exchanges at 2 Gy higher SER values and at 4 Gy lower SER values were 
      observed for both chromosomes.
FAU - Franken, N A
AU  - Franken NA
AD  - Academic Medical Centre, University of Amsterdam, Department of Radiotherapy, 
      1100 DE Amsterdam, The Netherlands.
FAU - van Bree, C
AU  - van Bree C
FAU - Veltmaat, M A
AU  - Veltmaat MA
FAU - Ludwikow, G
AU  - Ludwikow G
FAU - Kipp, J B
AU  - Kipp JB
FAU - Barendsen, G W
AU  - Barendsen GW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Radiation-Sensitizing Agents)
RN  - LGP81V5245 (Idoxuridine)
SB  - IM
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 2/drug effects/*radiation effects
MH  - DNA Damage
MH  - DNA Repair
MH  - Dose-Response Relationship, Radiation
MH  - *Gamma Rays
MH  - Humans
MH  - Idoxuridine/*pharmacology
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*pathology
MH  - Radiation-Sensitizing Agents/*pharmacology
MH  - Translocation, Genetic/drug effects/*radiation effects
MH  - Tumor Cells, Cultured/drug effects/radiation effects
MH  - X Chromosome/drug effects/*radiation effects
EDAT- 1998/12/29 00:00
MHDA- 1998/12/29 00:01
CRDT- 1998/12/29 00:00
PHST- 1998/12/29 00:00 [pubmed]
PHST- 1998/12/29 00:01 [medline]
PHST- 1998/12/29 00:00 [entrez]
AID - 10.3892/or.6.1.59 [doi]
PST - ppublish
SO  - Oncol Rep. 1999 Jan-Feb;6(1):59-63. doi: 10.3892/or.6.1.59.