PMID- 9864689
OWN - NLM
STAT- MEDLINE
DCOM- 19990210
LR  - 20161124
IS  - 0914-5087 (Print)
IS  - 0914-5087 (Linking)
VI  - 32
IP  - 5
DP  - 1998 Nov
TI  - [Evaluation of therapy for dilated cardiomyopathy with heart failure by 
      iodine-123 metaiodobenzylguanidine imaging: comparison with heart rate 
      variability power spectral analysis].
PG  - 323-9
AB  - The relationship between the myocardial uptake of iodine-123 
      metaiodobenzylguanidine (123I-MIBG) and heart rate variability parameters has not 
      been determined. This study determined the relationship between the change in 
      myocardial uptake of 123I-MIBG and improvement in left ventricular function after 
      treatment, to determine the usefulness of 123I-MIBG imaging to assess the effect 
      of therapy on heart failure due to dilated cardiomyopathy (DCM). 123I-MIBG 
      imaging and power spectral analysis of heart rate variability were performed 
      before and after treatment in 17 patients with heart failure due to DCM. The 
      following parameters were compared before and after treatment: New York Heart 
      Association (NYHA) functional class, radiographic cardiothoracic ratio (CTR), 
      blood pressure, echocardiographic data [left ventricular end-systolic (LVDs) and 
      end-diastolic (LVDd) diameters, left ventricular ejection fraction (LVEF)], 
      plasma concentrations of norepinephrine and epinephrine, heart rate variability 
      power spectral analysis data [mean low frequency (MLF) and high frequency power 
      (MHF)] and the myocardium to mediastinum activity ratio (MYO/M) obtained in early 
      and late images, and washout rate calculated by anterior planar imaging of 
      123I-MIBG. The NYHA functional class, LVEF, LVDs, CTR, MLF and MHF improved after 
      treatment. Early MYO/M and late MYO/M improved after treatment. The rate of 
      increase in late MYO/M was positively correlated with the rate of improvement of 
      LVEF after treatment. Furthermore, the late MYO/M was negatively correlated with 
      MLF. Washout rate revealed no correlation with hemodynamic parameters. These 
      findings suggest that late MYO/M is more useful than washout rate to assess the 
      effect of treatment on heart failure due to DCM. Furthermore, the 123I-MIBG 
      imaging and heart rate variability parameters are useful to assess the autonomic 
      tone in DCM with heart failure.
FAU - Li, S
AU  - Li S
AD  - First Department of Internal Medicine, Tohoku University School of Medicine, 
      Miyagi.
FAU - Ikeda, J
AU  - Ikeda J
FAU - Takita, T
AU  - Takita T
FAU - Sekiguchi, Y
AU  - Sekiguchi Y
FAU - Demachi, J
AU  - Demachi J
FAU - Chikama, H
AU  - Chikama H
FAU - Goto, A
AU  - Goto A
FAU - Shirato, K
AU  - Shirato K
LA  - jpn
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Diuretics)
RN  - 0 (Radiopharmaceuticals)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
RN  - 69PN84IO1A (Enalapril)
RN  - 73K4184T59 (Digoxin)
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - *3-Iodobenzylguanidine
MH  - Angiotensin-Converting Enzyme Inhibitors/therapeutic use
MH  - Cardiomyopathy, Dilated/diagnosis/*diagnostic imaging/drug therapy
MH  - Cardiotonic Agents/therapeutic use
MH  - Digoxin/therapeutic use
MH  - Diuretics/therapeutic use
MH  - Enalapril/therapeutic use
MH  - Female
MH  - Furosemide/therapeutic use
MH  - Heart Failure/drug therapy
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radionuclide Imaging
MH  - *Radiopharmaceuticals
MH  - Ventricular Function, Left
EDAT- 1998/12/29 00:00
MHDA- 1998/12/29 00:01
CRDT- 1998/12/29 00:00
PHST- 1998/12/29 00:00 [pubmed]
PHST- 1998/12/29 00:01 [medline]
PHST- 1998/12/29 00:00 [entrez]
PST - ppublish
SO  - J Cardiol. 1998 Nov;32(5):323-9.