PMID- 9865389
OWN - NLM
STAT- MEDLINE
DCOM- 19990216
LR  - 20170214
IS  - 0956-3202 (Print)
IS  - 0956-3202 (Linking)
VI  - 9
IP  - 6
DP  - 1998 Nov
TI  - Anti-picornavirus activity of synthetic flavon-3-yl esters.
PG  - 511-5
AB  - The in vitro antiviral activity against picornaviruses (rhinovirus serotype 1B 
      and 14, and poliovirus type 2) of new synthetic 3-hydroxyflavones, 
      3-acetoxyflavones, and substituted cinnamic and benzoic acid flavon-3-yl esters 
      was evaluated. The maximum non-toxic concentration of compounds was determined in 
      a human cell line (HeLa) suitable for the replication of the three viruses. Their 
      antiviral potency was measured by a plaque reduction assay. Generally, 
      rhinoviruses exhibited a higher sensitivity to the new flavonoids than 
      poliovirus. Flavones, with sterically small substituents in position 3, showed 
      good activity against both rhinoviruses tested. However, the introduction of 
      bulky substituents in the same position resulted in analogues with a higher 
      toxicity and often with a lower efficacy.
FAU - Conti, C
AU  - Conti C
AD  - Institute of Microbiology, School of Medicine, Rome, Italy. 
      desideri@axrma.uniroma1.it
FAU - Mastromarino, P
AU  - Mastromarino P
FAU - Sgro, R
AU  - Sgro R
FAU - Desideri, N
AU  - Desideri N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Antivir Chem Chemother
JT  - Antiviral chemistry & chemotherapy
JID - 9009212
RN  - 0 (Antiviral Agents)
RN  - 0 (Benzoates)
RN  - 0 (Cinnamates)
RN  - 0 (Coumaric Acids)
RN  - 0 (Flavonoids)
RN  - 0 (Hydroxybenzoates)
SB  - IM
MH  - Antiviral Agents/chemical synthesis/*pharmacology
MH  - Benzoates/chemical synthesis/*pharmacology
MH  - Cinnamates/chemical synthesis/*pharmacology
MH  - Coumaric Acids/chemical synthesis/pharmacology
MH  - Esterification
MH  - Flavonoids/chemical synthesis/*pharmacology
MH  - HeLa Cells
MH  - Humans
MH  - Hydroxybenzoates/chemical synthesis
MH  - Molecular Structure
MH  - Poliovirus/*drug effects/physiology
MH  - Rhinovirus/*drug effects/physiology
MH  - Structure-Activity Relationship
MH  - Viral Plaque Assay
MH  - Virus Replication/drug effects
EDAT- 1998/12/29 00:00
MHDA- 1998/12/29 00:01
CRDT- 1998/12/29 00:00
PHST- 1998/12/29 00:00 [pubmed]
PHST- 1998/12/29 00:01 [medline]
PHST- 1998/12/29 00:00 [entrez]
AID - 10.1177/095632029800900607 [doi]
PST - ppublish
SO  - Antivir Chem Chemother. 1998 Nov;9(6):511-5. doi: 10.1177/095632029800900607.