PMID- 9865721
OWN - NLM
STAT- MEDLINE
DCOM- 19990125
LR  - 20131121
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 58
IP  - 24
DP  - 1998 Dec 15
TI  - Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for 
      hypoxic/anoxic p53 induction.
PG  - 5678-80
AB  - Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 
      expression and hence select for p53-mutant tumor cells with diminished apoptotic 
      potential. It has been proposed that the hypoxia-inducible factor-1 (HIF-1) alpha 
      subunit binds to p53 and protects it from proteasomal degradation. However, we 
      found that hypoxic conditions that strongly induce HIF-1-dependent endogenous 
      gene expression as well as HIF-1alpha protein neither induce p53-dependent gene 
      expression nor p53 protein. The iron chelator deferoxamine induced both 
      HIF-1alpha and p53, but p53 up-regulation could still be detected in 
      HIF-1alpha-deficient cells, suggesting that mechanisms other than HIF-1alpha 
      activation contribute to oxygen-regulated p53 induction.
FAU - Wenger, R H
AU  - Wenger RH
AD  - Institute of Physiology, University of Zurich-Irchel, Zurich, Switzerland.
FAU - Camenisch, G
AU  - Camenisch G
FAU - Desbaillets, I
AU  - Desbaillets I
FAU - Chilov, D
AU  - Chilov D
FAU - Gassmann, M
AU  - Gassmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (ARNT protein, human)
RN  - 0 (Arnt protein, mouse)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Transcription Factors)
RN  - 138391-32-9 (Aryl Hydrocarbon Receptor Nuclear Translocator)
RN  - J06Y7MXW4D (Deferoxamine)
SB  - IM
MH  - Animals
MH  - Aryl Hydrocarbon Receptor Nuclear Translocator
MH  - *Cell Hypoxia
MH  - DNA-Binding Proteins/*metabolism
MH  - Deferoxamine/pharmacology
MH  - *Gene Expression Regulation, Neoplastic
MH  - *Genes, p53
MH  - Humans
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Mice
MH  - Nuclear Proteins/*metabolism
MH  - *Receptors, Aryl Hydrocarbon
MH  - Transcription Factors/metabolism
MH  - Tumor Cells, Cultured
MH  - Up-Regulation
EDAT- 1998/12/29 00:00
MHDA- 1998/12/29 00:01
CRDT- 1998/12/29 00:00
PHST- 1998/12/29 00:00 [pubmed]
PHST- 1998/12/29 00:01 [medline]
PHST- 1998/12/29 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1998 Dec 15;58(24):5678-80.