PMID- 9868114
OWN - NLM
STAT- MEDLINE
DCOM- 19990210
LR  - 20061115
IS  - 1000-5625 (Print)
IS  - 1000-5625 (Linking)
VI  - 22
IP  - 3
DP  - 1997
TI  - [A preliminary study on p53 gene expression and infection of human papilloma 
      virus in laryngeal squamous cell carcinoma].
PG  - 209-11
AB  - Using immunohistochemical techniques with p53 monoclonal antibody DO-7 and 
      polymerase chain reaction with type specific primers, we detected the expression 
      of p53 of laryngeal and hypopharyngeal squamous cell carcinoma (L-HSCC) in 42 
      patients, tissues around tumor in 25 patients, human papilloma virus (HPV) 16/18 
      DNA in paraffinembedded carcinoma tissues from 13 patients with laryngeal 
      squamous cell carcinoma (LSCC). The results showed that overexpression of p53 was 
      detected in 54.8% (23/42) of L-GSCC and 20% (5/25) of hyperlasia epithelia, 
      respectively. There was no correlation of p53 overexpression with clinical stages 
      and histological grading of tumors (P > 0.05). HPV16 DNA encoding E6 protein was 
      detected in 23.1% (3/13) LSCC tissues by PCR. The results suggest that 
      overexpression of p53 and HPV infection are not only associated with pathogenesis 
      of this kind of cancer but also cooperated during carcinogenesis.
FAU - Xie, M
AU  - Xie M
AD  - Department of Otolaryngology, Xiangya Hospital, Hunan Medical University, 
      Changsha.
FAU - Xiao, J
AU  - Xiao J
FAU - Tao, Z
AU  - Tao Z
FAU - Luo, J
AU  - Luo J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Hunan Yi Ke Da Xue Xue Bao
JT  - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical 
      University
JID - 9424769
RN  - 0 (E6 protein, Human papillomavirus type 16)
RN  - 0 (Oncogene Proteins, Viral)
RN  - 0 (Repressor Proteins)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics/*virology
MH  - Female
MH  - Gene Expression
MH  - Genes, p53
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/*virology
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Viral/analysis
MH  - *Papillomaviridae
MH  - *Papillomavirus Infections
MH  - *Repressor Proteins
MH  - Tumor Suppressor Protein p53/*biosynthesis
MH  - *Tumor Virus Infections
EDAT- 1997/01/01 00:00
MHDA- 1998/12/30 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/12/30 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Hunan Yi Ke Da Xue Xue Bao. 1997;22(3):209-11.