PMID- 9875237
OWN - NLM
STAT- MEDLINE
DCOM- 19990113
LR  - 20071115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 253
IP  - 1
DP  - 1998 Dec 9
TI  - Regulation of multifunctional Ca2+/calmodulin-dependent protein kinases by 
      Ca2+/calmodulin-dependent protein kinase phosphatase.
PG  - 159-63
AB  - We have recently reported a novel protein phosphatase which dephosphorylates and 
      thereby deactivates Ca2+/calmodulin-dependent protein kinase II (CaMKII) 
      activated through autophosphorylation (Ishida, A., Kameshita, I., and Fujisawa, 
      H. (1998) J. Biol. Chem. 273, 1904-1910). In the present study, we show that this 
      protein phosphatase also catalyzed dephosphorylation of Ca2+/calmodulin-dependent 
      protein kinases I (CaMKI) and IV (CaMKIV) which had been phosphorylated and 
      activated by Ca2+/calmodulin-dependent protein kinase kinase alpha, resulting in 
      reversible deactivation of the enzymes. The fairly high degree of the substrate 
      specificity of this protein phosphatase suggests that the physiological 
      significance of the phosphatase may be the regulation of the three 
      multifunctional Ca2+/calmodulin-dependent protein kinases, CaMKI, CaMKII, and 
      CaMKIV, which are the key enzymes in a Ca(2+)-signaling system in the cell.
FAU - Ishida, A
AU  - Ishida A
AD  - Department of Biochemistry, Asahikawa Medical College, Japan.
FAU - Okuno, S
AU  - Okuno S
FAU - Kitani, T
AU  - Kitani T
FAU - Kameshita, I
AU  - Kameshita I
FAU - Fujisawa, H
AU  - Fujisawa H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Multienzyme Complexes)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 1)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 4)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.17 (Camk1 protein, rat)
RN  - EC 2.7.11.17 (Camk4 protein, rat)
RN  - EC 2.7.11.17 (Pnck protein, rat)
RN  - EC 3.1.3.- (calmodulin dependent protein kinase II phosphatase)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
SB  - IM
MH  - Animals
MH  - Brain Stem/enzymology
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 1
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 4
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Enzyme Activation
MH  - Multienzyme Complexes/*metabolism
MH  - Phosphoprotein Phosphatases/*physiology
MH  - Rats
MH  - Substrate Specificity
EDAT- 1999/01/06 00:00
MHDA- 1999/01/06 00:01
CRDT- 1999/01/06 00:00
PHST- 1999/01/06 00:00 [pubmed]
PHST- 1999/01/06 00:01 [medline]
PHST- 1999/01/06 00:00 [entrez]
AID - S0006-291X(98)99771-6 [pii]
AID - 10.1006/bbrc.1998.9771 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1998 Dec 9;253(1):159-63. doi: 
      10.1006/bbrc.1998.9771.