PMID- 9875729
OWN - NLM
STAT- MEDLINE
DCOM- 19990324
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 9
IP  - 17
DP  - 1998 Dec 1
TI  - MK-801 and male odours induce c-fos expression in the AOB of juvenile female 
      mice.
PG  - 3919-24
AB  - The odours of adult males, which accelerate the timing of puberty of female mice, 
      activate c-fos in the accessory olfactory bulb (AOB). To test the hypothesis that 
      NMDA receptors are involved in the male odour-induced increase in c-fos 
      expression, we studied the effects of the non-competitive NMDA receptor agonist 
      MK-801 on male odour-induced c-fos expression in the AOB of juvenile female mice. 
      Surprisingly, MK-801 increased FOS-like immunoreactivity (FLI) within the AOB in 
      the absence of male odour and had no effect on male odour-induced c-fos 
      expression. We suggest that MK-801 increases AOB mitral cell activity by 
      disinhibiting GABAergic granule cells, resulting in increased c-fos expression 
      throughout the AOB.
FAU - McLellan, R A
AU  - McLellan RA
AD  - Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.
FAU - Wilkinson, M
AU  - Wilkinson M
FAU - Brown, R E
AU  - Brown RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Sex Attractants)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Dizocilpine Maleate/*pharmacology
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - *Odorants
MH  - Olfactory Bulb/*drug effects/metabolism
MH  - Proto-Oncogene Proteins c-fos/*biosynthesis
MH  - Sex Attractants/*pharmacology
MH  - Sexual Maturation
EDAT- 1999/01/06 00:00
MHDA- 1999/01/06 00:01
CRDT- 1999/01/06 00:00
PHST- 1999/01/06 00:00 [pubmed]
PHST- 1999/01/06 00:01 [medline]
PHST- 1999/01/06 00:00 [entrez]
AID - 10.1097/00001756-199812010-00028 [doi]
PST - ppublish
SO  - Neuroreport. 1998 Dec 1;9(17):3919-24. doi: 10.1097/00001756-199812010-00028.