PMID- 9876899
OWN - NLM
STAT- MEDLINE
DCOM- 19990318
LR  - 20190905
IS  - 0009-9120 (Print)
IS  - 0009-9120 (Linking)
VI  - 31
IP  - 8
DP  - 1998 Nov
TI  - Interactions between essential and toxic elements in lead exposed children in 
      Katowice, Poland.
PG  - 657-65
AB  - OBJECTIVES: To determine the influence of the essential element status on blood 
      concentrations of lead and other toxic metals. DESIGN AND METHODS: A group of 157 
      children from Katowice, an industrial area in Poland, was investigated for 
      concentrations of lead and cadmium in whole blood, and mercury, selenium, zinc, 
      copper, and magnesium in whole blood and serum. Relations between these elements, 
      serum ferritin, hematological parameters, as well as serum selenoprotein P and 
      glutathione peroxidase (GSH-px) were examined. Conversion factors for element 
      concentrations (mumol to microgram): lead 207.19, cadmium 112.41, mercury 200.59, 
      selenium 78.96, magnesium 24.31, copper 63.55, and zinc 65. RESULTS: Blood lead 
      was negatively associated with concentrations of selenium in whole blood and 
      serum as well as selenoprotein P and glutathione peroxidase in serum. The 
      association was mainly apparent at low blood lead concentrations, which may 
      indicate an influence of selenium on the kinetics of lead, rather than an effect 
      of lead on the selenium status. Children with low serum ferritin levels had 
      statistically higher blood cadmium levels and a tendency for higher blood lead 
      levels, indicating increased gastrointestinal absorption of these metals at 
      reduced iron stores. Blood lead was negatively correlated with mean corpuscular 
      hemoglobin concentration, which may reflect the effect of lead on hemoglobin 
      synthesis. There was an association between blood mercury and selenium, 
      indicating a common source of intake through fish consumption. CONCLUSIONS: The 
      results indicate that selenium and iron status may influence the kinetics of 
      lead.
FAU - Osman, K
AU  - Osman K
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 
      katarina.osman@imm.ki.se
FAU - Schutz, A
AU  - Schutz A
FAU - Akesson, B
AU  - Akesson B
FAU - Maciag, A
AU  - Maciag A
FAU - Vahter, M
AU  - Vahter M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Proteins)
RN  - 0 (Selenoprotein P)
RN  - 0 (Selenoproteins)
RN  - 00BH33GNGH (Cadmium)
RN  - 789U1901C5 (Copper)
RN  - 9007-73-2 (Ferritins)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - FXS1BY2PGL (Mercury)
RN  - H6241UJ22B (Selenium)
RN  - I38ZP9992A (Magnesium)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Adolescent
MH  - Cadmium/blood
MH  - Child
MH  - Child, Preschool
MH  - Copper/blood
MH  - Female
MH  - Ferritins/blood
MH  - Glutathione Peroxidase/blood
MH  - Humans
MH  - Lead Poisoning/*blood/*prevention & control
MH  - Magnesium/blood
MH  - Male
MH  - Mass Spectrometry/*methods
MH  - Mercury/blood
MH  - Poland
MH  - Proteins/analysis
MH  - Selenium/blood
MH  - Selenoprotein P
MH  - Selenoproteins
MH  - Zinc/blood
EDAT- 1999/01/07 00:00
MHDA- 1999/01/07 00:01
CRDT- 1999/01/07 00:00
PHST- 1999/01/07 00:00 [pubmed]
PHST- 1999/01/07 00:01 [medline]
PHST- 1999/01/07 00:00 [entrez]
AID - S0009-9120(98)00071-X [pii]
AID - 10.1016/s0009-9120(98)00071-x [doi]
PST - ppublish
SO  - Clin Biochem. 1998 Nov;31(8):657-65. doi: 10.1016/s0009-9120(98)00071-x.