PMID- 9877033
OWN - NLM
STAT- MEDLINE
DCOM- 19990304
LR  - 20190814
IS  - 0340-6199 (Print)
IS  - 0340-6199 (Linking)
VI  - 157
IP  - 12
DP  - 1998 Dec
TI  - Clinical and haemodynamic correlates of heart rate variability in children with 
      congenital heart disease.
PG  - 967-71
AB  - Heart rate variability (HRV) represents a noninvasive parameter for studying the 
      autonomic control of the heart. Cardiac patients have a complex autonomic 
      disturbance. The relation of HRV to this abnormality in children with congenital 
      heart disease (CHD) has not yet been examined. The present study examined HRV 
      indices from 24 h Holter recordings in 258 children with an operated or 
      non-operated CHD, to determine their differences as an indicator of the severity 
      of heart disease. The latter was defined clinically as New York Heart Association 
      (NYHA) functional classes I to IV and haemodynamically by invasive parameters. 
      Five time-domain measures (SDNN, SDNNi, SDANNi, rMSSD and pNN50) and three 
      frequency-domain measures (LF, HF and balance LF/HF) were compared with normal 
      ranges. HRV was reduced in children with CHD, except in patients of NYHA class I. 
      The level of reduction depended on the NYHA functional class. None of the 
      measures was significantly related to haemodynamic data. CONCLUSION: Heart rate 
      variability is reduced in children with Congenital heart disease depending on the 
      functional limitation but not on haemodynamic disturbances. Heart rate 
      variability indices are sensitive markers of the clinical state.
FAU - Massin, M
AU  - Massin M
AD  - Department of Paediatric Cardiology, Klinikum der R.W.T.H. Aachen, Germany. 
      martial.massin@chrcitadelle.be
FAU - von Bernuth, G
AU  - von Bernuth G
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Electrocardiography, Ambulatory
MH  - Heart Defects, Congenital/classification/*physiopathology/surgery
MH  - Heart Rate/*physiology
MH  - Hemodynamics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Retrospective Studies
MH  - Signal Processing, Computer-Assisted
EDAT- 1999/01/07 00:00
MHDA- 1999/01/07 00:01
CRDT- 1999/01/07 00:00
PHST- 1999/01/07 00:00 [pubmed]
PHST- 1999/01/07 00:01 [medline]
PHST- 1999/01/07 00:00 [entrez]
AID - 10.1007/s004310050979 [doi]
PST - ppublish
SO  - Eur J Pediatr. 1998 Dec;157(12):967-71. doi: 10.1007/s004310050979.