PMID- 9877410
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20191210
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 65
IP  - 3
DP  - 1998 Dec 1
TI  - Intracerebroventricular (i.c.v.) administration of mouse leptin in rats: 
      behavioral specificity and effects on meal patterns.
PG  - 445-55
AB  - Leptin is a protein that is produced primarily in fat tissue and is thought to be 
      a lipostatic feedback signal for the regulation of body fat stores. The purpose 
      of this study was to determine the behavioral specificity of i.c.v.-administered 
      mouse leptin in rats and to assess the effects on meal patterns. Using a modified 
      two-bottle paradigm we examined the putative aversive response to i.c.v. doses of 
      1, 5, 7, 10, and 30 microg of mouse leptin. Artificial CSF and intraperitoneal 
      lithium chloride served as negative and positive controls, respectively. 
      Saccharin consumption in all leptin treatments was not significantly different 
      from the negative control. Following a recovery period, rats from the same group 
      were used to assess the effects of a 30-microg i.c.v. dose on cumulative food 
      intake and meal patterns using a computer-based system for acquisition of feeding 
      data. Leptin (i.c.v.) significantly increased intermeal interval and decreased 
      meal size. We, therefore, conclude that mouse leptin, at doses up to 30 microg 
      i.c.v., is not aversive in the rat, and that leptin has a multiphasic effect on 
      meal patterns.
FAU - Hulsey, M G
AU  - Hulsey MG
AD  - Department of Foods and Nutrition, The University of Georgia, Athens 30602, USA. 
      rjmartin@fcs.uga.edu
FAU - Lu, H
AU  - Lu H
FAU - Wang, T
AU  - Wang T
FAU - Martin, R J
AU  - Martin RJ
FAU - Baile, C A
AU  - Baile CA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Leptin)
RN  - 0 (Proteins)
RN  - 0 (Recombinant Proteins)
RN  - FST467XS7D (Saccharin)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects/physiology
MH  - Body Weight/drug effects
MH  - Conditioning, Psychological/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - Feeding Behavior/*drug effects
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Leptin
MH  - Male
MH  - Mice
MH  - Proteins/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recombinant Proteins/pharmacology
MH  - Saccharin/pharmacology
MH  - Taste/drug effects/physiology
EDAT- 1999/01/07 00:00
MHDA- 1999/01/07 00:01
CRDT- 1999/01/07 00:00
PHST- 1999/01/07 00:00 [pubmed]
PHST- 1999/01/07 00:01 [medline]
PHST- 1999/01/07 00:00 [entrez]
AID - S0031-9384(98)00180-2 [pii]
AID - 10.1016/s0031-9384(98)00180-2 [doi]
PST - ppublish
SO  - Physiol Behav. 1998 Dec 1;65(3):445-55. doi: 10.1016/s0031-9384(98)00180-2.