PMID- 9877452
OWN - NLM
STAT- MEDLINE
DCOM- 19990323
LR  - 20120618
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 18
IP  - 12
DP  - 1998 Dec
TI  - Binding of interleukin-18 to the interleukin-1 receptor homologous receptor 
      IL-1Rrp1 leads to activation of signaling pathways similar to those used by 
      interleukin-1.
PG  - 1077-88
AB  - Interleukin-18 (IL-18) is an inflammatory cytokine that has been shown to enhance 
      a variety of Th1 type T cell responses. Because IL-18 is homologous to IL-1, we 
      tested binding of IL-18 to the known IL-1R family members. We could show binding 
      of IL-18 to the orphan receptor IL-1Rrp1 but not to other IL-1R homologous 
      proteins. IL-1Rrp1 and IL-1RI share highly conserved domains within their 
      cytoplasmic regions. Comparison of the IL-1 and IL-18 signaling mechanisms showed 
      that they activate identical cytoplasmic messengers. IL-18, like IL-1, induced 
      association of its receptor with IRAK and subsequent recruitment of TRAF6. IL-18 
      activated p38 MAP kinase, jun kinase, and beta casein kinase (TIP kinase), an 
      apparently novel kinase previously thought to be specifically activated by IL-1 
      and tumor necrosis factor (TNF). IL-18 activated NF-kappaB in EL4/6.1 thymoma 
      cells but not in COS-7 cells, even though the latter presumably contain all 
      components required for the IL-1 signaling pathway. From our binding and 
      signaling studies, we conclude that the IL-18 receptor complex consists of IL-18, 
      the IL-1Rrp1, and another thus far unidentified receptor molecule.
FAU - Thomassen, E
AU  - Thomassen E
AD  - Immunex Corporation, Seattle, WA 98101, USA.
FAU - Bird, T A
AU  - Bird TA
FAU - Renshaw, B R
AU  - Renshaw BR
FAU - Kennedy, M K
AU  - Kennedy MK
FAU - Sims, J E
AU  - Sims JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-18)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Interleukin-1)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Casein Kinases)
RN  - EC 2.7.11.1 (TNF-IL1-activated protein kinase)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - COS Cells
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - *Casein Kinases
MH  - Cell Line
MH  - Enzyme Activation
MH  - Humans
MH  - Interleukin-1/*metabolism
MH  - Interleukin-18/*metabolism
MH  - Mice
MH  - NF-kappa B/metabolism
MH  - Precipitin Tests
MH  - Protein Kinases/metabolism
MH  - Receptors, Interleukin-1/*metabolism
MH  - Signal Transduction/*physiology
EDAT- 1999/01/07 00:00
MHDA- 1999/01/07 00:01
CRDT- 1999/01/07 00:00
PHST- 1999/01/07 00:00 [pubmed]
PHST- 1999/01/07 00:01 [medline]
PHST- 1999/01/07 00:00 [entrez]
AID - 10.1089/jir.1998.18.1077 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 1998 Dec;18(12):1077-88. doi: 
      10.1089/jir.1998.18.1077.