PMID- 9878022
OWN - NLM
STAT- MEDLINE
DCOM- 19990218
LR  - 20220408
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 179
IP  - 2
DP  - 1999 Feb
TI  - Epidemiology of enterotoxigenic Escherichia coli diarrhea in a pediatric cohort 
      in a periurban area of lower Egypt.
PG  - 382-9
AB  - Enterotoxigenic Escherichia coli (ETEC) are diverse pathogens that express 
      heat-labile (LT) and/or heat-stable (ST) enterotoxins, yet little is known about 
      whether epidemiologic patterns of pediatric ETEC diarrhea vary by the expressed 
      ETEC toxin phenotype. In total, 242 Egyptian children aged <3 years were 
      prospectively followed in 1993-1995. ETEC episodes were detected during 
      twice-weekly home visits, and asymptomatic ETEC excretion was identified from 
      monthly cross-sectional surveys. ETEC episodes were 0.6 per child-year. ST-only 
      ETEC was 2.6 times (P<.001) more common in warmer than cooler months, while 
      LT-only ETEC showed no seasonal variation. Ownership of a household sanitary 
      latrine, but not breast-feeding, was associated with a lower risk of both 
      enterotoxin phenotypes. Coexpression of a colonization factor by LT- or ST-only 
      ETEC strengthened the association with diarrhea. These findings indicate that the 
      epidemiologic patterns of LT-only and ST-only ETEC are not identical and that 
      disease interventions should include improved household sanitation.
FAU - Abu-Elyazeed, R
AU  - Abu-Elyazeed R
AD  - US Naval Medical Research Unit No. 3, Cairo, Egypt.
FAU - Wierzba, T F
AU  - Wierzba TF
FAU - Mourad, A S
AU  - Mourad AS
FAU - Peruski, L F
AU  - Peruski LF
FAU - Kay, B A
AU  - Kay BA
FAU - Rao, M
AU  - Rao M
FAU - Churilla, A M
AU  - Churilla AM
FAU - Bourgeois, A L
AU  - Bourgeois AL
FAU - Mortagy, A K
AU  - Mortagy AK
FAU - Kamal, S M
AU  - Kamal SM
FAU - Savarino, S J
AU  - Savarino SJ
FAU - Campbell, J R
AU  - Campbell JR
FAU - Murphy, J R
AU  - Murphy JR
FAU - Naficy, A
AU  - Naficy A
FAU - Clemens, J D
AU  - Clemens JD
LA  - eng
GR  - Y1-HD-0026-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Cohort Studies
MH  - Diarrhea, Infantile/*epidemiology/microbiology
MH  - Egypt/epidemiology
MH  - Escherichia coli/*pathogenicity
MH  - Escherichia coli Infections/*epidemiology/microbiology
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Prospective Studies
MH  - Urban Population
MH  - Virulence
EDAT- 1999/01/07 03:04
MHDA- 2000/03/21 09:00
CRDT- 1999/01/07 03:04
PHST- 1999/01/07 03:04 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/01/07 03:04 [entrez]
AID - JID980585 [pii]
AID - 10.1086/314593 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 Feb;179(2):382-9. doi: 10.1086/314593.