PMID- 9879018
OWN - NLM
STAT- MEDLINE
DCOM- 19990209
LR  - 20091119
IS  - 0016-6758 (Print)
IS  - 0016-6758 (Linking)
VI  - 34
IP  - 9
DP  - 1998 Sep
TI  - [Selective structure of the gene pool. II. Standard method using F(ST) 
      statistics].
PG  - 1307-21
AB  - A new approach to the description of the selective structure of the gene pool 
      that is determined by the type and intensity of selection for individual genes is 
      suggested. Selective pressure is defined based on the heterogeneity of the 
      interpopulation diversity index FST. It is assumed that a significant difference 
      between the estimated heterogeneity for the ith gene FST(i) and the selectively 
      neutral interpopulation differentiation of the gene pool (Fe) indicate an effect 
      of selection on the ith gene. In order to reveal such significant differences, 
      empirical FST(i) distributions for the human gene pools of all parts of the world 
      and five subregions of northeastern Eurasia were approximated by different 
      theoretical distributions. It was demonstrated that only beta-distributions 
      yielded a good approximation of the empirical FST(i) estimations in all studied 
      gene pools. Based on the beta-approximations, confidence intervals for FST were 
      calculated. These intervals allowed the genes to be divided into three classes of 
      selective structure. Class NEUTRAL comprised genes that were assumed to be 
      selectively neutral (FST(i) approximately equal to Fe); classes LOWER DIFF and 
      SUPER DIFF comprised selectively important genes with significantly decreased 
      (FST(i) < Fe) and increased (FST(i) > Fe) differentiation, respectively. 
      Positions of 80 immunologically important biochemical markers were determined in 
      the selective structure of the gene pools of six regions of the world: Europe, 
      Asia, Africa, Australia, America, and northwestern Eurasia. The suggested method 
      of estimating selective structure can be used if FST = Fe, where Fe is a 
      selectively neutral variation of genes. Fe = 4NeMe + 1)-1; the main conditions 
      for the use of this method are the following assumptions: (1) the genetic process 
      is stationary and (2) the effective population size (Ne), the migration rate 
      (Me), and the selection rate (S) are constant in time and space. If these 
      conditions are not met, a correction (numeric resampling) is required.
FAU - Balanovskaia, E V
AU  - Balanovskaia EV
AD  - Institute of Clinical Genetics, Research Center for Medical Genetics, Russian 
      Academy of Medical Sciences, Moscow, Russia.
FAU - Nurbaev, S D
AU  - Nurbaev SD
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Selektivnaia struktura genofonda. II. Standartnaia tekhnologiia opredeleniia 
      cherez F(ST)-statistiki.
PL  - Russia (Federation)
TA  - Genetika
JT  - Genetika
JID - 0047354
SB  - IM
MH  - *Gene Pool
MH  - Genetic Heterogeneity
MH  - Humans
MH  - *Models, Statistical
MH  - *Selection, Genetic
EDAT- 1999/01/08 00:00
MHDA- 1999/01/08 00:01
CRDT- 1999/01/08 00:00
PHST- 1999/01/08 00:00 [pubmed]
PHST- 1999/01/08 00:01 [medline]
PHST- 1999/01/08 00:00 [entrez]
PST - ppublish
SO  - Genetika. 1998 Sep;34(9):1307-21.