PMID- 9879683
OWN - NLM
STAT- MEDLINE
DCOM- 19990329
LR  - 20190724
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 161
IP  - 1
DP  - 1998 Nov 26
TI  - HLA-DR4 influences glial activity in Alzheimer's disease hippocampus.
PG  - 66-9
AB  - The importance of inflammatory/immune mechanisms in Alzheimer's disease is 
      supported by evidence that the human leukocyte antigen (HLA)-DR genotype 
      influences risk of the disease, with a protective effect associated with the 
      HLA-DR4 allele. We investigated the influence of the HLA-DR4 allele on glial 
      activity, assessed by quantification of glial fibrillary acidic protein (GFAP), 
      in hippocampal tissue from subjects with Alzheimer's disease. The mean GFAP level 
      was significantly higher in Alzheimer's disease hippocampal specimens lacking the 
      HLA-DR4 allele compared to specimens with similar neuropathological findings that 
      were HLA-DR4 positive. Apolipoprotein E genotype had no influence on GFAP levels. 
      These results indicate that HLA-DR4 may exert a protective influence on 
      Alzheimer's disease via modulation of glial activity.
FAU - Aisen, P S
AU  - Aisen PS
AD  - Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA. 
      paul_aisen@smtplink.mssm.edu
FAU - Luddy, A
AU  - Luddy A
FAU - Durner, M
AU  - Durner M
FAU - Reinhard, J F Jr
AU  - Reinhard JF Jr
FAU - Pasinetti, G M
AU  - Pasinetti GM
LA  - eng
GR  - AG05138/AG/NIA NIH HHS/United States
GR  - AG13799/AG/NIA NIH HHS/United States
GR  - AG14239/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Alleles
MH  - Alzheimer Disease/*immunology/metabolism/pathology/*physiopathology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - HLA-DR4 Antigen/genetics/*physiology
MH  - Hippocampus/*immunology/metabolism/pathology/*physiopathology
MH  - Humans
MH  - Neuroglia/*physiology
EDAT- 1999/01/08 03:02
MHDA- 2001/03/28 10:01
CRDT- 1999/01/08 03:02
PHST- 1999/01/08 03:02 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/01/08 03:02 [entrez]
AID - S0022-510X(98)00268-8 [pii]
AID - 10.1016/s0022-510x(98)00268-8 [doi]
PST - ppublish
SO  - J Neurol Sci. 1998 Nov 26;161(1):66-9. doi: 10.1016/s0022-510x(98)00268-8.