PMID- 9880042
OWN - NLM
STAT- MEDLINE
DCOM- 19990311
LR  - 20190909
IS  - 0197-4580 (Print)
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 19
IP  - 5
DP  - 1998 Sep-Oct
TI  - Life-long overexpression of S100beta in Down's syndrome: implications for 
      Alzheimer pathogenesis.
PG  - 401-5
AB  - Chronic overexpression of the neurite growth-promoting factor S100beta has been 
      implicated in the pathogenesis of neuritic plaques in Alzheimer's disease. Such 
      plaques are virtually universal in middle-aged Down's syndrome, making Down's a 
      natural model of Alzheimer's disease. We determined numbers of astrocytes 
      overexpressing S100beta, and of neurons overexpressing beta-amyloid precursor 
      protein (beta-APP), and assayed for neurofibrillary tangles in neocortex of 20 
      Down's syndrome patients (17 weeks gestation to 68 years). Compared to controls, 
      there were twice as many S100beta-immunoreactive (S100beta+) astrocytes in Down's 
      patients at all ages: fetal, young, and adult (p = 0.01, or better, in each age 
      group). These were activated (i.e., enlarged), and intensely immunoreactive, even 
      in the fetal group. There were no neurofibrillary changes in fetal or young 
      Down's patients. The numbers of S100beta+ astrocytes in young and adult Down's 
      patients correlated with the numbers of neurons overexpressing beta-APP (p < 
      0.05). Our findings are consistent with the idea that conditions--including 
      Down's syndrome--that promote chronic overexpression of S100beta may confer 
      increased risk for later development of Alzheimer's disease.
FAU - Griffin, W S
AU  - Griffin WS
AD  - Geriatric Research, Education, and Clinical Center of the Department of Veterans' 
      Affairs Medical Center, University of Arkansas for Medical Sciences, Little Rock 
      72205, USA. griffinsuet@exchange.uams.edu
FAU - Sheng, J G
AU  - Sheng JG
FAU - McKenzie, J E
AU  - McKenzie JE
FAU - Royston, M C
AU  - Royston MC
FAU - Gentleman, S M
AU  - Gentleman SM
FAU - Brumback, R A
AU  - Brumback RA
FAU - Cork, L C
AU  - Cork LC
FAU - Del Bigio, M R
AU  - Del Bigio MR
FAU - Roberts, G W
AU  - Roberts GW
FAU - Mrak, R E
AU  - Mrak RE
LA  - eng
GR  - P01 AG012411/AG/NIA NIH HHS/United States
GR  - AG 10208/AG/NIA NIH HHS/United States
GR  - AG12411/AG/NIA NIH HHS/United States
GR  - NS 27414/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (S100 Proteins)
RN  - 0 (S100A1 protein)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Alzheimer Disease/*etiology/*metabolism/pathology
MH  - Amyloid beta-Peptides/analysis
MH  - Astrocytes/pathology
MH  - Brain/growth & development/metabolism
MH  - Brain Chemistry
MH  - Cell Count
MH  - Child
MH  - Child, Preschool
MH  - Down Syndrome/*metabolism/pathology
MH  - Fetus/chemistry/metabolism
MH  - Humans
MH  - Infant
MH  - Middle Aged
MH  - Neurons/chemistry/pathology
MH  - S100 Proteins/analysis/*biosynthesis
MH  - tau Proteins/analysis
PMC - PMC3833593
MID - NIHMS524652
EDAT- 1999/01/08 00:00
MHDA- 1999/01/08 00:01
PMCR- 2013/11/19
CRDT- 1999/01/08 00:00
PHST- 1999/01/08 00:00 [pubmed]
PHST- 1999/01/08 00:01 [medline]
PHST- 1999/01/08 00:00 [entrez]
PHST- 2013/11/19 00:00 [pmc-release]
AID - S0197-4580(98)00074-8 [pii]
AID - 10.1016/s0197-4580(98)00074-8 [doi]
PST - ppublish
SO  - Neurobiol Aging. 1998 Sep-Oct;19(5):401-5. doi: 10.1016/s0197-4580(98)00074-8.