PMID- 9883877
OWN - NLM
STAT- MEDLINE
DCOM- 19990122
LR  - 20231213
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 441
IP  - 2
DP  - 1998 Dec 18
TI  - Velcro in the nuclear envelope: LBR and LAPs.
PG  - 165-9
AB  - The nuclear envelope is crucial for the functional organization of the nucleus. 
      Lamin B receptor (LBR) and several lamina-associated proteins (LAPs), residing in 
      the inner membrane, provide attachment sites for chromatin and the nuclear 
      lamina. LAPs and LAP-related proteins are members of a growing family of 
      proteins, whose genes are expressed in a tissue and development specific manner, 
      opening the opportunity for a complex regulation of membrane-chromatin and 
      membrane-lamina interactions. Post-translational modifications of LBR and LAPs 
      are likely to modulate their binding to lamins and chromatin, interactions that 
      need to be dynamic to accommodate nuclear growth in interphase and nuclear 
      envelope disassembly in mitosis. Accumulation of proteins in the inner nuclear 
      membrane is believed to depend on their retention mediated by the interaction 
      with nuclear components such as chromatin and lamins.
FAU - Chu, A
AU  - Chu A
AD  - Department of Physiology, Montreal, Que, Canada.
FAU - Rassadi, R
AU  - Rassadi R
FAU - Stochaj, U
AU  - Stochaj U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Laminin)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
SB  - IM
MH  - Laminin/*metabolism
MH  - Nuclear Envelope/*metabolism
MH  - Phosphorylation
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - Lamin B Receptor
RF  - 43
EDAT- 1999/01/12 00:00
MHDA- 1999/01/12 00:01
CRDT- 1999/01/12 00:00
PHST- 1999/01/12 00:00 [pubmed]
PHST- 1999/01/12 00:01 [medline]
PHST- 1999/01/12 00:00 [entrez]
AID - S0014-5793(98)01534-8 [pii]
AID - 10.1016/s0014-5793(98)01534-8 [doi]
PST - ppublish
SO  - FEBS Lett. 1998 Dec 18;441(2):165-9. doi: 10.1016/s0014-5793(98)01534-8.