PMID- 9886508
OWN - NLM
STAT- MEDLINE
DCOM- 19990512
LR  - 20190512
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 13
IP  - 12
DP  - 1998 Dec
TI  - Studies on associations between human leukocyte antigen (HLA) class II alleles 
      and antiphospholipid antibodies in Danish and Czech women with recurrent 
      miscarriages.
PG  - 3326-31
AB  - Autoantibody production is commonly associated with particular HLA class II 
      phenotypes. The aim of the present study was to investigate whether the presence 
      of antiphospholipid (APL) antibodies and other autoantibodies in women with 
      unexplained recurrent miscarriage was associated with particular human leukocyte 
      antigen (HLA)-DR or -DQ alleles or linked epitopes which have previously been 
      reported as being associated with the recurrent miscarriage syndrome or the 
      presence of APL. In a total of 123 Danish and Czech women with recurrent 
      miscarriage, serum was investigated for six different APL antibodies including 
      anticardiolipin (ACL) antibody. Antinuclear antibodies (ANA), anti-zona pellucida 
      antibodies and anti-sperm antibodies were also investigated. The women were 
      HLA-DR and -DQ typed by DNA-based methods. The frequency of HLA-DR phenotypes did 
      not differ significantly between APL antibody positive recurrent miscarriage 
      patients and APL antibody negative recurrent miscarriage patients or healthy 
      controls. Among ACL antibody positive recurrent miscarriage patients, 
      significantly more were positive for the HLA-DR3 phenotype and negative for the 
      HLA-DR2 phenotypes compared with healthy controls (P < 0.05). Among ANA positive 
      recurrent miscarriage women, 55% carried the HLA-DR3 phenotype compared with 28% 
      of ANA negative patients (P < 0.05) and 21% of healthy controls (P < 0.002). In 
      conclusion, among recurrent miscarriage women, the HLA-DR3 phenotypes seem to 
      predispose to formation of ACL antibodies and ANA. The association between APL 
      antibodies and particular HLA alleles and HLA-linked epitopes reported in studies 
      of patients with lupus erythematosus (e.g. HLA-DR7 and -DR4) could not be 
      confirmed in patients with recurrent miscarriage.
FAU - Christiansen, O B
AU  - Christiansen OB
AD  - Department of Obstetrics and Gynaecology, Aalborg Hospital, Denmark.
FAU - Ulcova-Gallova, Z
AU  - Ulcova-Gallova Z
FAU - Mohapeloa, H
AU  - Mohapeloa H
FAU - Krauz, V
AU  - Krauz V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Abortion, Habitual/*genetics/*immunology
MH  - Adult
MH  - Alleles
MH  - Antibodies, Antiphospholipid/*immunology
MH  - Czech Republic
MH  - Denmark
MH  - Female
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Pregnancy
EDAT- 1999/01/14 00:00
MHDA- 1999/01/14 00:01
CRDT- 1999/01/14 00:00
PHST- 1999/01/14 00:00 [pubmed]
PHST- 1999/01/14 00:01 [medline]
PHST- 1999/01/14 00:00 [entrez]
AID - 10.1093/humrep/13.12.3326 [doi]
PST - ppublish
SO  - Hum Reprod. 1998 Dec;13(12):3326-31. doi: 10.1093/humrep/13.12.3326.