PMID- 9888998
OWN - NLM
STAT- MEDLINE
DCOM- 19990304
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 55
IP  - 1
DP  - 1999 Jan 1
TI  - A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 
      11q13.
PG  - 49-56
AB  - We have generated a transcript map of an approximately 1.2-Mb region from human 
      chromosome band 11q13 between the loci VEGFB and CAPN1, which flank the multiple 
      endocrine neoplasia type 1 (MEN 1) locus. In total, we isolated 144 cosmids from 
      this region and generated a sequence-ready cosmid contig of the approximately 
      500-kb region between the neurexin locus and D11S2196E. We identified 54 
      genes/ESTs by sample sequencing and have constructed a transcript map of this 
      region. Genes were found to be clustered in three regions, and one of these genes 
      was identical to the recently identified MEN1 locus. Relative to the latter, we 
      have mapped the positions of 13 known genes, 18 genes which show homology to 
      genes from humans or other organisms, and 22 genes/ESTs that appear novel. In 
      addition, we have ascertained the directions of transcription of some of these 
      genes and have determined intergenic distances between many loci. Full 
      characterization of some of these genes, as well as the novel ESTs, will be 
      useful in identifying candidate genes for other diseases known to map to this 
      chromosomal region.
CI  - Copyright 1999 Academic Press.
FAU - Bergman, L
AU  - Bergman L
AD  - Queensland Cancer Fund Research Unit, Joint Experimental Oncology Program, 
      Queensland Institute of Medical Research, Herston, Queensland, 4029, Australia.
FAU - Silins, G
AU  - Silins G
FAU - Grimmond, S
AU  - Grimmond S
FAU - Hummerich, H
AU  - Hummerich H
FAU - Stewart, C
AU  - Stewart C
FAU - Little, P
AU  - Little P
FAU - Hayward, N
AU  - Hayward N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - *Chromosomes, Human, Pair 11
MH  - Contig Mapping
MH  - *Cosmids
MH  - Expressed Sequence Tags
MH  - Genes, Synthetic
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Nerve Tissue Proteins/genetics
MH  - RNA, Messenger/genetics
MH  - Transcription, Genetic
EDAT- 1999/01/16 00:00
MHDA- 1999/01/16 00:01
CRDT- 1999/01/16 00:00
PHST- 1999/01/16 00:00 [pubmed]
PHST- 1999/01/16 00:01 [medline]
PHST- 1999/01/16 00:00 [entrez]
AID - S0888-7543(98)95625-7 [pii]
AID - 10.1006/geno.1998.5625 [doi]
PST - ppublish
SO  - Genomics. 1999 Jan 1;55(1):49-56. doi: 10.1006/geno.1998.5625.