PMID- 9891550
OWN - NLM
STAT- MEDLINE
DCOM- 19990129
LR  - 20061115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 18
IP  - 6B
DP  - 1998 Nov-Dec
TI  - Angiogenesis: prognostic significance in laryngeal cancer.
PG  - 4737-40
AB  - The aim of this study was to evaluate the role of angiogenesis in the progression 
      of laryngeal squamous cell carcinoma (LSCC). We correlated disease-free survival 
      with microvessel count (MC) in the hot spot areas of 97 randomly selected 
      caucasian males with LSCC followed for 60 to 90 months after surgery with or 
      without radiotherapy. The results obtained indicate that: a) MC higher than 130 
      microvessels/mm2 is a cut-off value that distinguished patients who relapsed 
      during the follow up period; b) multivariated analysis indicates that MC (p < 
      0.00001) is an independent predictor of disease free-survival; c) multivariated 
      analysis selectively done on cases with relapse demonstrates that MC correlates 
      with the presence of metastasis (or/and M) with local relapse (T). We suggest 
      that MC is useful in the assessment of prognosis in LSCC and probably will permit 
      selection of patients that could benefit from anti-angiogenic therapy associated 
      with chemotherapy and/or radiotherapy.
FAU - Beatrice, F
AU  - Beatrice F
AD  - Divisione di Otorinolaringoiatria, Ospedale Giovanni Bosco, Torino, Italy.
FAU - Cammarota, R
AU  - Cammarota R
FAU - Giordano, C
AU  - Giordano C
FAU - Corrado, S
AU  - Corrado S
FAU - Ragona, R
AU  - Ragona R
FAU - Sartoris, A
AU  - Sartoris A
FAU - Bussolino, F
AU  - Bussolino F
FAU - Valente, G
AU  - Valente G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Disease-Free Survival
MH  - Humans
MH  - Laryngeal Neoplasms/*blood supply/mortality/*pathology/radiotherapy/surgery
MH  - Male
MH  - Microcirculation/*pathology
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Neovascularization, Pathologic/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Recurrence
MH  - Survival Rate
MH  - Time Factors
EDAT- 1999/01/19 00:00
MHDA- 1999/01/19 00:01
CRDT- 1999/01/19 00:00
PHST- 1999/01/19 00:00 [pubmed]
PHST- 1999/01/19 00:01 [medline]
PHST- 1999/01/19 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1998 Nov-Dec;18(6B):4737-40.