PMID- 9891715
OWN - NLM
STAT- MEDLINE
DCOM- 19990129
LR  - 20191102
IS  - 0889-857X (Print)
IS  - 0889-857X (Linking)
VI  - 24
IP  - 4
DP  - 1998 Nov
TI  - Pathogenesis of human leukocyte antigen B27-positive arthritis. Information from 
      clinical materials.
PG  - 865-81, xi
AB  - In the spondyloarthropathies human leukocyte antigen (HLA) B27 confers a strong 
      genetic predisposition to the development and to the chronicity of disease after 
      extra-articular infection with certain gram-negative bacteria. The close 
      relationships between infection, HLA-B27, other genetic factors, and the host 
      immune system, however, still are unexplained. HLA-B27-positive arthritis 
      continues to be an area of intensive investigation in basic and clinical 
      research. New animal models with HLA-B27 transgenic mice and rats, as well as 
      recent developments in understanding the processes involved in signal 
      transduction, cytokine production, and human T-lymphocyte activation, contribute 
      to the development of new pathogenic models of the spondyloarthropathies. This 
      article summarizes the current concepts of the cause and pathogenesis of the 
      spondyloarthropathies resulting from studies of clinical materials. The 
      host-microbial interplay in human disease, namely in bacteria-induced reactive 
      arthritis, may eludicate principle disease mechanisms in acute disease and in the 
      development of chronic autoimmune arthritis or ankylosing spondylitis.
FAU - Marker-Hermann, E
AU  - Marker-Hermann E
AD  - First Department of Medicine, Johannes Gutenberg University of Mainz, Germany. 
      emaerker@goofy.zdv.uni-mainz.de
FAU - Hohler, T
AU  - Hohler T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Rheum Dis Clin North Am
JT  - Rheumatic diseases clinics of North America
JID - 8708093
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Animals
MH  - Arthritis, Reactive/*etiology/*immunology
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
RF  - 82
EDAT- 1999/01/19 00:00
MHDA- 1999/01/19 00:01
CRDT- 1999/01/19 00:00
PHST- 1999/01/19 00:00 [pubmed]
PHST- 1999/01/19 00:01 [medline]
PHST- 1999/01/19 00:00 [entrez]
AID - S0889-857X(05)70046-6 [pii]
AID - 10.1016/s0889-857x(05)70046-6 [doi]
PST - ppublish
SO  - Rheum Dis Clin North Am. 1998 Nov;24(4):865-81, xi. doi: 
      10.1016/s0889-857x(05)70046-6.