PMID- 9892619
OWN - NLM
STAT- MEDLINE
DCOM- 19990223
LR  - 20200304
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 189
IP  - 2
DP  - 1999 Jan 18
TI  - Fcgamma receptor-mediated induction of dendritic cell maturation and major 
      histocompatibility complex class I-restricted antigen presentation after immune 
      complex internalization.
PG  - 371-80
AB  - Dendritic cells (DCs) express several receptors for the Fc portion of 
      immunoglobulin (Ig)G (FcgammaR), which mediate internalization of antigen-IgG 
      complexes (immune complexes, ICs) and promote efficient major histocompatibility 
      complex (MHC) class II-restricted antigen presentation. We now show that 
      FcgammaRs have two additional specific attributes in murine DCs: the induction of 
      DC maturation and the promotion of efficient MHC class I-restricted presentation 
      of peptides from exogenous, IgG-complexed antigens. Both FcgammaR functions 
      require the FcgammaR-associated gamma chain. FcgammaR-mediated MHC class 
      I-restricted antigen presentation is extremely sensitive and specific to immature 
      DCs. It requires proteasomal degradation and is dependent on functional peptide 
      transporter associated with antigen processing, TAP1-TAP2. By promoting DC 
      maturation and presentation on both MHC class I and II molecules, ICs should 
      efficiently sensitize DCs for priming of both CD4(+) helper and CD8(+) cytotoxic 
      T lymphocytes in vivo.
FAU - Regnault, A
AU  - Regnault A
AD  - Institut National de la Sante et de la Recherche Medicale CJF 95-01, Institut 
      Curie, Section Recherche, 75005 Paris, France.
FAU - Lankar, D
AU  - Lankar D
FAU - Lacabanne, V
AU  - Lacabanne V
FAU - Rodriguez, A
AU  - Rodriguez A
FAU - Thery, C
AU  - Thery C
FAU - Rescigno, M
AU  - Rescigno M
FAU - Saito, T
AU  - Saito T
FAU - Verbeek, S
AU  - Verbeek S
FAU - Bonnerot, C
AU  - Bonnerot C
FAU - Ricciardi-Castagnoli, P
AU  - Ricciardi-Castagnoli P
FAU - Amigorena, S
AU  - Amigorena S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Antigens, CD)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Receptors, IgG)
RN  - 0 (TAP1 protein, human)
RN  - 0 (Tap1 protein, mouse)
RN  - 0 (Tap2 protein, mouse)
RN  - 145892-13-3 (TAP2 protein, human)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/immunology
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Antigen-Antibody Complex/*immunology
MH  - Antigens, CD/immunology
MH  - Bone Marrow/immunology
MH  - Cysteine Endopeptidases/metabolism
MH  - Dendritic Cells/*immunology
MH  - Fluorescent Antibody Technique
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Immunoglobulin G/immunology
MH  - Lipopolysaccharides/pharmacology
MH  - Mice
MH  - Mice, Knockout
MH  - Multienzyme Complexes/metabolism
MH  - Ovalbumin/immunology
MH  - Proteasome Endopeptidase Complex
MH  - Receptors, IgG/*immunology
PMC - PMC2192989
EDAT- 1999/01/20 00:00
MHDA- 1999/01/20 00:01
PMCR- 1999/07/18
CRDT- 1999/01/20 00:00
PHST- 1999/01/20 00:00 [pubmed]
PHST- 1999/01/20 00:01 [medline]
PHST- 1999/01/20 00:00 [entrez]
PHST- 1999/07/18 00:00 [pmc-release]
AID - 10.1084/jem.189.2.371 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Jan 18;189(2):371-80. doi: 10.1084/jem.189.2.371.