PMID- 9893290
OWN - NLM
STAT- MEDLINE
DCOM- 19990304
LR  - 20190915
IS  - 0374-5600 (Print)
IS  - 0374-5600 (Linking)
VI  - 40
IP  - 6
DP  - 1998 Dec
TI  - Juvenile chronic arthritis profile in Greek children.
PG  - 558-63
AB  - BACKGROUND: Juvenile chronic arthritis (JCA) is the commonest autoimmune 
      rheumatic disease in childhood and presents different clinical subtypes. Juvenile 
      chronic arthritis is considered to be of a polygenic nature and its genetic 
      background is still under investigation. The clinical profile of JCA in the Greek 
      population has not been studied completely. This study retrospectively analyzed 
      the clinical and immunological features of JCA in Greek children presented 
      between 1989 and 1994. Human leukocyte antigen (HLA)-positive or -negative 
      associations in the different clinical subtypes were also detected. The findings 
      of this study were correlated with those reported from other populations. METHODS 
      AND RESULTS: Antinuclear antibodies (ANA) anti-ds DNA and anti-extractable 
      nuclear antigen antibodies were estimated by immunofluorescent and ELISA assays. 
      Human leukocyte antigen typing was performed by microlymphocytotoxicity, using 
      immunobeads. The peak ages of JCA onset were between 2 and 5 years and also 
      between 9 and 12 years. There was a high female predominance in pauciarticular 
      and polyarticular groups. The most common disease was pauciarticular (58.7%) 
      followed by systemic (25%) arthritis. The incidence of eye involvement was 12.5% 
      and presented only in the pauciarticular group. Overall, ANA positivity was 
      53.7%, increasing to 90% in pauciarticular cases associated with chronic uveitis. 
      In the early onset (EOPA) pauciarticular subtype, positive-HLA associations with 
      alleles DR11 and DR8 were shown. In the late onset pauciarticular (LOPA) group 
      only B27 allele was increased. CONCLUSIONS: The results of this retrospective 
      study did not reveal major differences between JCA in Greek children compared 
      with other Caucasian series.
FAU - Dracou, C
AU  - Dracou C
AD  - 1st Department of Paediatrics, Aghia Sophia Children's Hospital, Athens, Greece.
FAU - Constantinidou, N
AU  - Constantinidou N
FAU - Constantopoulos, A
AU  - Constantopoulos A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Acta Paediatr Jpn
JT  - Acta paediatrica Japonica : Overseas edition
JID - 0370357
RN  - 0 (Antibodies, Antinuclear)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Antibodies, Antinuclear/*blood
MH  - Arthritis, Juvenile/blood/complications/*immunology
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Greece/epidemiology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Retrospective Studies
MH  - Uveitis/etiology
EDAT- 1999/01/20 00:00
MHDA- 1999/01/20 00:01
CRDT- 1999/01/20 00:00
PHST- 1999/01/20 00:00 [pubmed]
PHST- 1999/01/20 00:01 [medline]
PHST- 1999/01/20 00:00 [entrez]
AID - 10.1111/j.1442-200x.1998.tb01990.x [doi]
PST - ppublish
SO  - Acta Paediatr Jpn. 1998 Dec;40(6):558-63. doi: 
      10.1111/j.1442-200x.1998.tb01990.x.