PMID- 9893302
OWN - NLM
STAT- MEDLINE
DCOM- 19990304
LR  - 20190915
IS  - 0374-5600 (Print)
IS  - 0374-5600 (Linking)
VI  - 40
IP  - 6
DP  - 1998 Dec
TI  - Trisomy 6 in a childhood acute mixed lineage leukemia.
PG  - 616-20
AB  - The patient is a 12-year-old boy with acute mixed lineage leukemia (AMLL) and 
      with a rare karyotype of trisomy 6. He was referred to our hospital with gingival 
      swelling, bleeding at the conjunctiva and huge hepatosplenomegaly. Complete blood 
      count revealed leukocytosis with 79% blasts, anemia and thrombocytopenia. Bone 
      marrow examination revealed 82.5% blasts which were morphologically judged as M1 
      according to the French-American-British classification. Immunophenotyping of 
      leukemic cells showed the presence of CD2, CD7, CD19 and CD13 antigens, 
      suggesting the diagnosis of AMLL. Cytogenetic analysis revealed a single abnormal 
      karyotype of 47,XY,+6,add(15)(q22) which was successfully detected by 
      fluorescence in situ hybridization (FISH) with the probe mapping at the 
      alpha-satellite region of chromosome 6. Although the patient was treated with 
      several chemotherapy regimens, he could not achieve complete remission and he 
      died of progressive disease 11 months after admission. Fluorescence in situ 
      hybridization analysis was very informative in assessing the residual leukemic 
      cells in interphase during his clinical course.
FAU - Onodera, N
AU  - Onodera N
AD  - Section of Pediatrics, Iwate Prefectural Kitakami Hospital, Japan. 
      Norio@Kitakami.ne.jp
FAU - Nakahata, T
AU  - Nakahata T
FAU - Tanaka, H
AU  - Tanaka H
FAU - Ito, R
AU  - Ito R
FAU - Honda, T
AU  - Honda T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Acta Paediatr Jpn
JT  - Acta paediatrica Japonica : Overseas edition
JID - 0370357
SB  - IM
MH  - Child
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Fatal Outcome
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Biphenotypic, Acute/diagnosis/*genetics
MH  - Male
MH  - Trisomy/*genetics
EDAT- 1999/01/20 00:00
MHDA- 1999/01/20 00:01
CRDT- 1999/01/20 00:00
PHST- 1999/01/20 00:00 [pubmed]
PHST- 1999/01/20 00:01 [medline]
PHST- 1999/01/20 00:00 [entrez]
AID - 10.1111/j.1442-200x.1998.tb02002.x [doi]
PST - ppublish
SO  - Acta Paediatr Jpn. 1998 Dec;40(6):616-20. doi: 
      10.1111/j.1442-200x.1998.tb02002.x.