PMID- 9894564
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190921
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 40
IP  - 6
DP  - 1998 Dec
TI  - Peripheral blood mononuclear cells from women with recurrent abortion exhibit an 
      aberrant reaction to release cytokines upon the direct contact of human leukocyte 
      antigen-G-expressing cells.
PG  - 408-13
AB  - PROBLEM: In search for pathogenesis of recurrent abortion, we examined whether 
      lymphocytes/macrophages from women with recurrent abortion exhibited an aberrant 
      ability to release cytokines upon the direct contact of human leukocyte antigen 
      (HLA)-G. METHOD OF STUDY: The amounts of cytokines released from peripheral blood 
      mononuclear cells (PBMCs) from women with recurrent abortion were compared with 
      those from normal multiparous women or normal nulligravidous women when 
      cocultured with or without HLA-G-expressing target cells. RESULTS: When 
      cocultured with HLA-G-expressing target cells, the amount of interleukin-1 beta 
      released from PBMCs was increased in recurrent aborters whereas it decreased in 
      both normal multiparous and nulligravidous women. The amount of interleukin-3 
      released from PBMCs did not differ with or without HLA-G-expressing cells in 
      recurrent aborters, whereas it increased in the presence of HLA-G-expressing 
      cells in normal controls. The amount of tumor necrosis factor-alpha released from 
      PBMCs was decreased in the presence of HLA-G-expressing cells in both recurrent 
      aborters and normal controls. CONCLUSION: The aberrant reaction of maternal 
      lymphocytes/macrophages in releasing cytokines upon the contact of HLA-G 
      expressed on trophoblasts may impact negatively on trophoblastic growth, which 
      may be pathogenic in recurrent abortion.
FAU - Hamai, Y
AU  - Hamai Y
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Tokyo, Japan.
FAU - Fujii, T
AU  - Fujii T
FAU - Yamashita, T
AU  - Yamashita T
FAU - Miki, A
AU  - Miki A
FAU - Kozuma, S
AU  - Kozuma S
FAU - Geraghty, D E
AU  - Geraghty DE
FAU - Taketani, Y
AU  - Taketani Y
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-3)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Abortion, Habitual/*immunology
MH  - Adult
MH  - Cell Line
MH  - Cytokines/*metabolism
MH  - Female
MH  - HLA Antigens/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Interleukin-1/metabolism
MH  - Interleukin-3/metabolism
MH  - Leukocytes, Mononuclear/*immunology
MH  - Pregnancy
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1999/01/23 00:00
MHDA- 1999/01/23 00:01
CRDT- 1999/01/23 00:00
PHST- 1999/01/23 00:00 [pubmed]
PHST- 1999/01/23 00:01 [medline]
PHST- 1999/01/23 00:00 [entrez]
AID - 10.1111/j.1600-0897.1998.tb00426.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 1998 Dec;40(6):408-13. doi: 
      10.1111/j.1600-0897.1998.tb00426.x.