PMID- 9914956
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20071115
IS  - 0914-5087 (Print)
IS  - 0914-5087 (Linking)
VI  - 32
IP  - 6
DP  - 1998 Dec
TI  - [Effectiveness of surgical repair of mitral regurgitation concomitant with 
      dilated cardiomyopathy].
PG  - 391-6
AB  - Dilated cardiomyopathy (DCM) is often accompanied by severe mitral regurgitation 
      (MR) which deteriorates the clinical course. Mitral reconstruction for severe MR 
      may improve the symptoms and prognosis. Five patients with DCM and one patient 
      with dilated phase of hypertrophic cardiomyopathy underwent mitral reconstruction 
      for severe MR (4 males, 2 females, mean age 50 +/- 17 years) from 1983 to 1995. 
      Their New York Heart Association (NYHA) functional class and findings of 
      echocardiography and cardiac catheterization were compared before and after 
      surgery. Five patients underwent annuloplasty and one patient underwent 
      mechanical valve replacement. There was no operative or in-hospital death. NYHA 
      class improved from 3.2 to 1.8 (p < 0.05). The degree of MR was reduced from 3.5 
      to 1.2 (p < 0.05), and left ventricular end-diastolic pressure decreased from 18 
      +/- 7 to 13 +/- 8 mmHg (p < 0.05). Left ventricular fractional shortening, 
      ejection fraction and cardiac index (2.4 +/- 0.4 to 2.7 +/- 1.1 l/min/m2) did not 
      change significantly. Two patients died within one year due to exacerbation of 
      congestive heart failure (2.5 month later) or sudden death (6 months later). 
      Three patients died at 21 months, 5 and 8 years after the operation (renal 
      insufficiency, heart failure, sudden death, respectively). Mitral reconstruction 
      improved the symptoms in patients with DCM and severe MR in the short term. 
      However, 5 of 6 patients died in the intermediate or long-term. Mitral 
      reconstruction may be a therapeutic option for early outcome in patients with 
      refractory congestive heart failure due to DCM and severe MR.
FAU - Tomita, T
AU  - Tomita T
AD  - Department of Cardiology, National Cardiovascular Center, Osaka.
FAU - Nakatani, S
AU  - Nakatani S
FAU - Eishi, K
AU  - Eishi K
FAU - Takemura, T
AU  - Takemura T
FAU - Takasawa, A
AU  - Takasawa A
FAU - Koyanagi, H
AU  - Koyanagi H
FAU - Kameda, Y
AU  - Kameda Y
FAU - Kitamura, S
AU  - Kitamura S
FAU - Komamura, K
AU  - Komamura K
FAU - Yasumura, Y
AU  - Yasumura Y
FAU - Yamagishi, M
AU  - Yamagishi M
FAU - Miyatake, K
AU  - Miyatake K
LA  - jpn
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/etiology
MH  - Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/surgery
MH  - Mitral Valve Insufficiency/etiology/*surgery
MH  - Treatment Outcome
EDAT- 1999/01/23 00:00
MHDA- 1999/01/23 00:01
CRDT- 1999/01/23 00:00
PHST- 1999/01/23 00:00 [pubmed]
PHST- 1999/01/23 00:01 [medline]
PHST- 1999/01/23 00:00 [entrez]
PST - ppublish
SO  - J Cardiol. 1998 Dec;32(6):391-6.