PMID- 9915569
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20101118
IS  - 0741-0395 (Print)
IS  - 0741-0395 (Linking)
VI  - 16
IP  - 1
DP  - 1999
TI  - Indication of linkage of serum IgE levels to the interleukin-4 gene and exclusion 
      of the contribution of the (-590 C to T) interleukin-4 promoter polymorphism to 
      IgE variation.
PG  - 84-94
AB  - Previous segregation analysis of a sample of 234 randomly selected Australian 
      families showed evidence for a recessive major gene controlling serum 
      immunoglobulin E (IgE) levels independently of the specific response to allergens 
      (SRA). Since linkage has been recently reported between serum IgE levels and the 
      5q candidate region spanning the interleukin-4 (IL-4) gene, we investigated 
      whether the recessive major gene detected by segregation analysis was linked to 
      the IL-4 region and whether polymorphisms within the IL-4 gene were associated 
      with IgE levels. Both sib-pair method and combined segregation and linkage 
      analysis using the regressive models were applied to our data. Whereas there was 
      no evidence of linkage of total IgE levels to the IL-4 region, an indication of 
      linkage (P values ranging between 0.01 and 0.03) was found between IgE levels 
      adjusted for SRA and two IL-4 polymorphisms: one dinucleotide repeat in intron 2 
      of the IL-4 gene and a single nucleotide (-590 C to T) polymorphism in the IL-4 
      promoter. However, the putative IL-4 linked gene did not appear to be in linkage 
      disequilibrium with either of these two polymorphisms. A contribution of the IL-4 
      promoter polymorphism, presumed to be a potential functional variant influencing 
      IgE variation, was also excluded.
FAU - Dizier, M H
AU  - Dizier MH
AD  - INSERM U155, Universite de Paris 7, France.
FAU - Sandford, A
AU  - Sandford A
FAU - Walley, A
AU  - Walley A
FAU - Philippi, A
AU  - Philippi A
FAU - Cookson, W
AU  - Cookson W
FAU - Demenais, F
AU  - Demenais F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Epidemiol
JT  - Genetic epidemiology
JID - 8411723
RN  - 0 (Allergens)
RN  - 0 (Genetic Markers)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Australia
MH  - Child
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Hypersensitivity, Immediate/genetics
MH  - Immunoglobulin E/*blood
MH  - Interleukin-4/*genetics
MH  - Likelihood Functions
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Regression Analysis
EDAT- 1999/01/23 19:27
MHDA- 2000/06/20 09:00
CRDT- 1999/01/23 19:27
PHST- 1999/01/23 19:27 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/01/23 19:27 [entrez]
AID - 10.1002/(SICI)1098-2272(1999)16:1<84::AID-GEPI7>3.0.CO;2-D [pii]
AID - 10.1002/(SICI)1098-2272(1999)16:1<84::AID-GEPI7>3.0.CO;2-D [doi]
PST - ppublish
SO  - Genet Epidemiol. 1999;16(1):84-94. doi: 
      10.1002/(SICI)1098-2272(1999)16:1<84::AID-GEPI7>3.0.CO;2-D.