PMID- 9916070
OWN - NLM
STAT- MEDLINE
DCOM- 19990309
LR  - 20200724
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 67
IP  - 2
DP  - 1999 Feb
TI  - Role of adult worm antigen-specific immunoglobulin E in acquired immunity to 
      Schistosoma mansoni infection in baboons.
PG  - 636-42
AB  - Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate 
      with protective immunity in human schistosomiasis. To better understand the 
      mechanisms of parasite elimination we examined the immune correlates of 
      protection in baboons (Papio cynocephalus anubis), which are natural hosts for 
      Schistosoma mansoni and also develop allergic-type immunity with infection. In 
      one experiment, animals were exposed to a single infection (1,000 cercariae) or 
      were exposed multiple times (100 cercariae per week for 10 weeks) and 
      subsequently were cured with praziquantel prior to challenge with 1, 000 
      cercariae. Singly and multiply infected animals mounted 59 and 80% reductions in 
      worm burden, respectively (P < 0.01). In a second experiment, animals were 
      inoculated with S. mansoni ova and recombinant human interleukin 12 (IL-12). This 
      produced a 37 to 39% reduction in adult worm burden after challenge (P < 0.05). 
      Parasite-specific IgG, IgE, IgM, and peripheral blood cytokine production were 
      evaluated. The only immune correlate of protection in both experiments was levels 
      of soluble adult worm antigen (SWAP)-specific IgE in serum at the time of 
      challenge infection and/or 6 weeks later. Baboons repeatedly infected with 
      cercariae or immunized with ova and IL-12 developed two- to sixfold-greater 
      levels of SWAP-specific IgE in serum than did controls, and this correlated with 
      reductions in worm burden (r2, -0.40 to -0.64; P, <0. 01). Thus, in baboons and 
      unlike mice, adult worm-specific IgE is uniquely associated with acquired 
      immunity to S. mansoni infection. This similar association of parasite-specific 
      IgE and protection among primates infected with schistosomiasis, along with 
      similar pathology, anatomy, and genetic make-up, indicates that baboons provide 
      an excellent permissive experimental model for better understanding the 
      mechanisms of innate and acquired immunity to schistosomiasis in humans.
FAU - Nyindo, M
AU  - Nyindo M
AD  - Division of Infectious Diseases, Institute of Primate Research, National Museums 
      of Kenya, Karen, Nairobi, Kenya.
FAU - Kariuki, T M
AU  - Kariuki TM
FAU - Mola, P W
AU  - Mola PW
FAU - Farah, I O
AU  - Farah IO
FAU - Elson, L
AU  - Elson L
FAU - Blanton, R E
AU  - Blanton RE
FAU - King, C L
AU  - King CL
LA  - eng
GR  - AI01202/AI/NIAID NIH HHS/United States
GR  - AI35935/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antigens, Helminth)
RN  - 0 (Recombinant Proteins)
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens, Helminth/immunology
MH  - Cell Division
MH  - Cells, Cultured
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Interleukin-12/*immunology/pharmacology
MH  - Lymphocytes/cytology/immunology
MH  - Male
MH  - Papio
MH  - Recombinant Proteins/immunology/pharmacology
MH  - Schistosoma mansoni/*immunology
MH  - Schistosomiasis mansoni/*immunology/prevention & control
PMC - PMC96366
EDAT- 1999/01/23 00:00
MHDA- 1999/01/23 00:01
PMCR- 1999/02/01
CRDT- 1999/01/23 00:00
PHST- 1999/01/23 00:00 [pubmed]
PHST- 1999/01/23 00:01 [medline]
PHST- 1999/01/23 00:00 [entrez]
PHST- 1999/02/01 00:00 [pmc-release]
AID - 0988 [pii]
AID - 10.1128/IAI.67.2.636-642.1999 [doi]
PST - ppublish
SO  - Infect Immun. 1999 Feb;67(2):636-42. doi: 10.1128/IAI.67.2.636-642.1999.