PMID- 991828
OWN - NLM
STAT- MEDLINE
DCOM- 19770129
LR  - 20131121
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 99
IP  - 5
DP  - 1976 Nov
TI  - Dopamine/neuroleptic receptors in basal hypothalamus and pituitary.
PG  - 1407-6
AB  - In order to determine whether the basal hypothalamus or the pituitary (or both) 
      is the likely locus of action of the tuberoinfundibular (TI) dopamine neurons, 
      these regions were examined for dopamine and neuroleptic receptors. High affinity 
      receptors for haloperidol and dopamine were found in the rat pituitary while none 
      were detected in rat basal hypothalamus. The relative ability of two 
      neuroleptics, chlorpromazine and haloperidol, to displace (3H)haloperidol from 
      the receptor in monkey pituitary is similar to that for rat striatum. The lack of 
      receptors capable of binding (3H)haloperidol or (3H)dopamine in the basal 
      hypothalamus strongly suggests that the TI neurons do not produce postsynaptic 
      effects in this region. The pituitary receptors for (3H)haloperidol and 
      (3H)dopamine have the characteristics of a functional system. The presence of 
      neuroleptic/dopamine receptors in the pituitary and lack of such receptors in the 
      basal hypothalamus supports the hypothesis that dopamine may act directly as a 
      prolactin release inhibiting factor (PIF) rather than releasing PIF from adjacent 
      nerve terminals in the median eminence.
FAU - Brown, G M
AU  - Brown GM
FAU - Seeman, P
AU  - Seeman P
FAU - Lee, T
AU  - Lee T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, Drug)
RN  - J6292F8L3D (Haloperidol)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Animals
MH  - Chlorpromazine/metabolism
MH  - Haloperidol/metabolism
MH  - Hypothalamus/*analysis
MH  - Kinetics
MH  - Male
MH  - Pituitary Gland/*analysis
MH  - Rats
MH  - Receptors, Dopamine/*analysis
MH  - Receptors, Drug/*analysis/metabolism
EDAT- 1976/11/01 00:00
MHDA- 1976/11/01 00:01
CRDT- 1976/11/01 00:00
PHST- 1976/11/01 00:00 [pubmed]
PHST- 1976/11/01 00:01 [medline]
PHST- 1976/11/01 00:00 [entrez]
AID - 10.1210/endo-99-5-1407 [doi]
PST - ppublish
SO  - Endocrinology. 1976 Nov;99(5):1407-6. doi: 10.1210/endo-99-5-1407.