PMID- 9919735 OWN - NLM STAT- MEDLINE DCOM- 19990222 LR - 20051116 IS - 0300-8495 (Print) IS - 0300-8495 (Linking) VI - 27 IP - 12 DP - 1998 Dec TI - Long acting beta agonists. PG - 1115-8 AB - Long acting beta agonists (LABAs) such as salmeterol and eformoterol provide 12 hour bronchodilatation, giving continuous control of asthma symptoms particularly at night. More recent evidence also suggests a role as 'steroid-sparing' agents, allowing control of asthma at lower doses of inhaled corticosteroids (ICS). Providing a sufficient dose of inhaled steroid (in adults around 800 micrograms of belcomethasone or budesonide or 400 micrograms of fluticasone) is used in conjunction with LABAs, there is no evidence of any increase in asthma exacerbation. Cost is the major impediment to the widespread application of these useful agents. FAU - Bowler, S AU - Bowler S AD - Mater Adult Hospital. LA - eng PT - Journal Article PT - Review PL - Australia TA - Aust Fam Physician JT - Australian family physician JID - 0326701 RN - 0 (Adrenal Cortex Hormones) RN - 0 (Adrenergic beta-Agonists) SB - IM MH - Adrenal Cortex Hormones/administration & dosage MH - Adrenergic beta-Agonists/*administration & dosage/adverse effects/pharmacology MH - Adult MH - Asthma/*drug therapy MH - Australia MH - Dose-Response Relationship, Drug MH - Drug Therapy, Combination MH - Humans MH - Prognosis MH - Treatment Outcome RF - 10 EDAT- 1999/01/27 00:00 MHDA- 1999/01/27 00:01 CRDT- 1999/01/27 00:00 PHST- 1999/01/27 00:00 [pubmed] PHST- 1999/01/27 00:01 [medline] PHST- 1999/01/27 00:00 [entrez] PST - ppublish SO - Aust Fam Physician. 1998 Dec;27(12):1115-8.