PMID- 9921898
OWN - NLM
STAT- MEDLINE
DCOM- 19990209
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 103
IP  - 6
DP  - 1998 Dec
TI  - FISH studies of the sperm of fathers of paternally derived cases of trisomy 21: 
      no evidence for an increase in aneuploidy.
PG  - 654-7
AB  - Paternal nondisjunction accounts for approximately 5% of cases of trisomy 21. To 
      test the hypothesis that, in some such cases, the fathers might be predisposed to 
      meiotic nondisjunction, we utilized fluorescence in situ hybridization (FISH) to 
      screen for aneuploidy in sperm. We analyzed sperm samples from ten males with a 
      trisomy 21 offspring of paternal origin. Among these individuals, the overall 
      frequency of disomy 21 was 0.15%, comparable to estimates of disomy 21 in the 
      general male population. Furthermore, none of the ten fathers of trisomy 21 
      individuals had significantly elevated levels of disomic sperm. Thus, our results 
      provide no evidence that the occurrence of a trisomy 21 conceptus of paternal 
      origin imparts an increased risk of trisomy in subsequent pregnancies.
FAU - Hixon, M
AU  - Hixon M
AD  - Department of Genetics and The Center for Human Genetics, Case Western Reserve 
      University and University Hospitals of Cleveland, OH 44106, USA. mlh7@po.cwru.edu
FAU - Millie, E
AU  - Millie E
FAU - Judis, L A
AU  - Judis LA
FAU - Sherman, S
AU  - Sherman S
FAU - Allran, K
AU  - Allran K
FAU - Taft, L
AU  - Taft L
FAU - Hassold, T
AU  - Hassold T
LA  - eng
GR  - P01 HD32111/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - *Aneuploidy
MH  - Diploidy
MH  - Down Syndrome/*etiology/genetics
MH  - *Fathers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Risk Factors
MH  - Single-Blind Method
MH  - *Spermatozoa
EDAT- 1999/01/28 00:00
MHDA- 1999/01/28 00:01
CRDT- 1999/01/28 00:00
PHST- 1999/01/28 00:00 [pubmed]
PHST- 1999/01/28 00:01 [medline]
PHST- 1999/01/28 00:00 [entrez]
AID - 10.1007/s004390050886 [doi]
PST - ppublish
SO  - Hum Genet. 1998 Dec;103(6):654-7. doi: 10.1007/s004390050886.