PMID- 9922935
OWN - NLM
STAT- MEDLINE
DCOM- 19990329
LR  - 20191102
IS  - 0889-8588 (Print)
IS  - 0889-8588 (Linking)
VI  - 12
IP  - 6
DP  - 1998 Dec
TI  - Low-molecular-weight heparins.
PG  - 1251-81, vi-vii
AB  - Low-molecular-weight heparins (LMWH) are a new group of parenteral 
      anticoagulants. They represent a major clinical advance in anticoagulation since 
      the identification of unfractionated heparin (UFH) in 1922 and the introduction 
      of the synthetic coumarin derivative, warfarin, in 1948. Their predictable 
      pharmacokinetics, increased bioavailability, and longer plasma half-life allow 
      for once- or twice-daily dosing and eliminate the need for routine laboratory 
      monitoring. This simplified administration stands to alter the clinical practice 
      of anticoagulation. This review high-lights recent clinical trials and focuses on 
      studies comparing LMWH with the other two major anticoagulants: UFH and coumadin.
FAU - Huang, J N
AU  - Huang JN
AD  - Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, 
      Massachusetts, USA.
FAU - Shimamura, A
AU  - Shimamura A
LA  - eng
GR  - K08-HD01203/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Hematol Oncol Clin North Am
JT  - Hematology/oncology clinics of North America
JID - 8709473
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 5Q7ZVV76EI (Warfarin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/therapeutic use
MH  - Cerebrovascular Disorders/drug therapy
MH  - Clinical Trials as Topic
MH  - Coronary Disease/drug therapy
MH  - Heparin/therapeutic use
MH  - Heparin, Low-Molecular-Weight/pharmacokinetics/*therapeutic use
MH  - Humans
MH  - Pulmonary Embolism/drug therapy
MH  - Venous Thrombosis/drug therapy
MH  - Warfarin/therapeutic use
RF  - 90
EDAT- 1999/01/29 00:00
MHDA- 1999/01/29 00:01
CRDT- 1999/01/29 00:00
PHST- 1999/01/29 00:00 [pubmed]
PHST- 1999/01/29 00:01 [medline]
PHST- 1999/01/29 00:00 [entrez]
AID - S0889-8588(05)70052-6 [pii]
AID - 10.1016/s0889-8588(05)70052-6 [doi]
PST - ppublish
SO  - Hematol Oncol Clin North Am. 1998 Dec;12(6):1251-81, vi-vii. doi: 
      10.1016/s0889-8588(05)70052-6.