PMID- 9923932
OWN - NLM
STAT- MEDLINE
DCOM- 19990212
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 30
IP  - 1
DP  - 1999 Jan
TI  - Polysomies but not Y chromosome losses have prognostic significance in pTa/pT1 
      urinary bladder cancer.
PG  - 81-6
AB  - A disturbed cellular DNA content is of potential diagnostic and prognostic 
      relevance in urinary bladder cancer. To evaluate the prognostic significance of 
      individual chromosomal aberrations in superficial bladder cancer, specimens of 
      105 tumors (67 pTa, 38 pT1) were examined by fluorescence in situ hybridization 
      (FISH). FISH allows quantitation of chromosomes on a cell by cell level. 
      Centromere probes for the chromosomes Y, 1, and 17 were used. There was a strong 
      association between polysomies of the chromosomes 1 (found in 46% of tumors) and 
      17 (40% of tumors, P < .0001). Polysomies (1 and 17) were significantly more 
      frequent in pT1 than in pTa tumors (P < .0001 each). In pTa tumors, polysomies of 
      both chromosomes were linked to a high risk of recurrences; polysomy 17 was 
      associated with an increased risk of progression (P < .05 each). There was no 
      significant association between polysomies and an unfavorable prognosis in pT1 
      carcinomas. Previous studies had suggested a prognostic role of Y losses in 
      bladder cancer. However, Y losses were not linked to recurrences or tumor 
      progression in pTa or pT1 tumors of 67 male patients. These data show that marked 
      genetic differences exist between pTa and pT1 carcinomas. They also indicate that 
      polysomies of different chromosomes may have prognostic relevance in pTa urinary 
      bladder cancer.
FAU - Neuhaus, M
AU  - Neuhaus M
AD  - Institute for Pathology and Urologic Clinics, University of Basel, Switzerland.
FAU - Wagner, U
AU  - Wagner U
FAU - Schmid, U
AU  - Schmid U
FAU - Ackermann, D
AU  - Ackermann D
FAU - Zellweger, T
AU  - Zellweger T
FAU - Maurer, R
AU  - Maurer R
FAU - Alund, G
AU  - Alund G
FAU - Knonagel, H
AU  - Knonagel H
FAU - Rist, M
AU  - Rist M
FAU - Moch, H
AU  - Moch H
FAU - Mihatsch, M J
AU  - Mihatsch MJ
FAU - Gasser, T C
AU  - Gasser TC
FAU - Sauter, G
AU  - Sauter G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/*diagnosis/genetics/surgery
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/genetics/pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sex Chromosome Aberrations/*genetics
MH  - Urinary Bladder Neoplasms/*diagnosis/genetics/surgery
MH  - Y Chromosome/*genetics
EDAT- 1999/01/29 00:00
MHDA- 1999/01/29 00:01
CRDT- 1999/01/29 00:00
PHST- 1999/01/29 00:00 [pubmed]
PHST- 1999/01/29 00:01 [medline]
PHST- 1999/01/29 00:00 [entrez]
AID - S0046-8177(99)90305-2 [pii]
AID - 10.1016/s0046-8177(99)90305-2 [doi]
PST - ppublish
SO  - Hum Pathol. 1999 Jan;30(1):81-6. doi: 10.1016/s0046-8177(99)90305-2.