PMID- 9926843
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 9
IP  - 18
DP  - 1998 Dec 21
TI  - Potent suppressive effects of urocortin on splenic lymphocyte activity in rats.
PG  - 4035-9
AB  - To assess the possible role of urocortin, a recently identified neuropeptide 
      related to corticotropin-releasing factor (CRF), in modulation of peripheral 
      immune functions, the effects of intracranially administrated urocortin on the 
      proliferative activity of splenic lymphocytes were examined in rats. 
      Intracerebroventricular (i.c.v.) injection of urocortin (1 ng) produced a marked 
      decrease in the proliferative response of splenocytes to a mitogen. The 
      suppressive effect of urocortin was abolished by pretreatment with a ganglionic 
      blocking agent (chlorisondamine) or a beta-adrenergic receptor antagonist 
      (propranolol), but not by adrenalectomy. These results suggest that urocortin is 
      an important neuropeptide involved in the brain control of peripheral immune 
      functions such as stress-induced immunosuppression, and that the suppressive 
      effect of urocortin is mediated by the sympathetic nervous system.
FAU - Okamoto, S
AU  - Okamoto S
AD  - Department of Biomedical Sciences, School of Veterinary Medicine, Hokkaido 
      University, Sapporo, Japan.
FAU - Ishikawa, I
AU  - Ishikawa I
FAU - Kimura, K
AU  - Kimura K
FAU - Saito, M
AU  - Saito M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Ganglionic Blockers)
RN  - 0 (Urocortins)
RN  - 11028-71-0 (Concanavalin A)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenalectomy
MH  - Adrenergic beta-Antagonists/pharmacology
MH  - Animals
MH  - Concanavalin A/pharmacology
MH  - Corticosterone/blood
MH  - Corticotropin-Releasing Hormone/*pharmacology
MH  - Female
MH  - Ganglionic Blockers/pharmacology
MH  - Injections, Intraventricular
MH  - Lymphocytes/*drug effects/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Spleen/*cytology/*drug effects
MH  - Urocortins
EDAT- 1999/02/02 00:00
MHDA- 1999/02/02 00:01
CRDT- 1999/02/02 00:00
PHST- 1999/02/02 00:00 [pubmed]
PHST- 1999/02/02 00:01 [medline]
PHST- 1999/02/02 00:00 [entrez]
AID - 10.1097/00001756-199812210-00009 [doi]
PST - ppublish
SO  - Neuroreport. 1998 Dec 21;9(18):4035-9. doi: 10.1097/00001756-199812210-00009.