PMID- 9927014
OWN - NLM
STAT- MEDLINE
DCOM- 19990323
LR  - 20190831
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 31
IP  - 1
DP  - 1999 Jan
TI  - Substrate utilization and glucose turnover during exercise of varying intensities 
      in individuals with NIDDM.
PG  - 82-9
AB  - PURPOSE: This investigation was undertaken to examine substrate utilization and 
      glucose turnover during exercise of varying intensities in NIDDM patients. 
      METHODS: Six male NIDDM patients (N) and six male controls (C) of similar age, 
      body weight, % body fat, and VO2peak were studied in two experimental sessions 
      administered in a randomized counterbalanced order. During each session the 
      subjects cycled at a power output corresponding to 50% of VO2peak or 70% of 
      VO2peak. Duration of exercise was adjusted so that energy expenditure (EE) was 
      equal in both the 50% and 70% trials. Isotope infusion technique and indirect 
      calorimetry were used to assess substrate utilization and glucose turnover during 
      exercise. RESULTS: Rates of carbohydrate (CHO) and lipid oxidation increased (P < 
      0.05) during both the 50% and 70% trials. Rates of CHO oxidation were greater (P 
      < 0.05) during the 70% than during the 50% trial. However, rates of lipid 
      oxidation were similar in the two trials. No differences in rates of CHO and 
      lipid oxidation were observed in N and C. Rates of hepatic glucose production 
      (Ra) and plasma glucose utilization (Rd) increased (P < 0.05) during exercise, 
      and the increases were similar in the 50% and 70% trials. Ra did not differ 
      between N and C. However, Rd was greater (P < 0.05) in N than in C. Plasma 
      glucose concentration decreased (P < 0.05) in N, with the decrease being similar 
      in the 50% and 70% trials. In contrast, plasma glucose concentration remained 
      unchanged during both the 50% and 70% trials in C. CONCLUSIONS: Exercise results 
      in a greater increase in plasma glucose utilization in patients with NIDDM 
      compared with that in normal individuals, and this increase mediates the decline 
      in plasma glucose concentrations in patients with NIDDM. Under isocaloric 
      conditions, the changes in plasma glucose utilization and plasma glucose 
      concentrations are similar during exercise of varying intensities. Despite a 
      greater glucose utilization, carbohydrate and fat oxidation are similar in the 
      two groups and their relations to exercise intensity are not altered by NIDDM.
FAU - Kang, J
AU  - Kang J
AD  - Department of Health and Exercise Science, Rowan University, Glassboro, NJ 08028, 
      USA. kang@rowan.edu
FAU - Kelley, D E
AU  - Kelley DE
FAU - Robertson, R J
AU  - Robertson RJ
FAU - Goss, F L
AU  - Goss FL
FAU - Suminski, R R
AU  - Suminski RR
FAU - Utter, A C
AU  - Utter AC
FAU - Dasilva, S G
AU  - Dasilva SG
LA  - eng
GR  - DK 46204/DK/NIDDK NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Blood Glucose)
RN  - 0 (Fats)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Carbohydrate Metabolism
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Exercise/*physiology
MH  - Fats/metabolism
MH  - Glycogen/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/physiology
MH  - Oxidation-Reduction
EDAT- 1999/02/02 00:00
MHDA- 1999/02/02 00:01
CRDT- 1999/02/02 00:00
PHST- 1999/02/02 00:00 [pubmed]
PHST- 1999/02/02 00:01 [medline]
PHST- 1999/02/02 00:00 [entrez]
AID - 10.1097/00005768-199901000-00014 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 1999 Jan;31(1):82-9. doi: 10.1097/00005768-199901000-00014.