PMID- 9927230
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20181113
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 7
IP  - 6
DP  - 1998
TI  - Perpetuation of inflammation associated with experimental arthritis: the role of 
      macrophage activation by neutrophilic myeloperoxidase.
PG  - 381-9
AB  - Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine 
      infiltration of inflamed joints. This study addresses a previously unrecognized 
      interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) 
      which could explain the perpetuation of inflammation associated with RA. A 
      monoarticular arthritis was induced in female Lewis rats by injection of 
      streptococcal cell wall extracts (PG-APS). After swelling and erythema subsided, 
      joints were re-injected with one of the following: porcine MPO or partially 
      inactivated MPO (iMPO). Injection with either MPO or iMPO induced a 'flare' of 
      experimental RA. Blocking the Mphi-mannose receptor by mannans, ablated 
      exacerbation of disease. These results indicate that MPO or iMPO can play a 
      pivotal role in the perpetuation but not initiation of this RA model.
FAU - Gelderman, M P
AU  - Gelderman MP
AD  - National Institutes of Health, Bethesda, MD 20931, USA.
FAU - Stuart, R
AU  - Stuart R
FAU - Vigerust, D
AU  - Vigerust D
FAU - Fuhrmann, S
AU  - Fuhrmann S
FAU - Lefkowitz, D L
AU  - Lefkowitz DL
FAU - Allen, R C
AU  - Allen RC
FAU - Lefkowitz, S S
AU  - Lefkowitz SS
FAU - Graham, S
AU  - Graham S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/*immunology/pathology
MH  - Disease Models, Animal
MH  - Female
MH  - Macrophage Activation/*immunology
MH  - Macrophages/*immunology
MH  - Neutrophils/*enzymology
MH  - Peroxidase/*immunology
MH  - Rats
MH  - Rats, Inbred Lew
PMC - PMC1781873
EDAT- 1999/02/02 00:00
MHDA- 1999/02/02 00:01
PMCR- 1998/01/01
CRDT- 1999/02/02 00:00
PHST- 1999/02/02 00:00 [pubmed]
PHST- 1999/02/02 00:01 [medline]
PHST- 1999/02/02 00:00 [entrez]
PHST- 1998/01/01 00:00 [pmc-release]
AID - 10.1080/09629359890758 [doi]
PST - ppublish
SO  - Mediators Inflamm. 1998;7(6):381-9. doi: 10.1080/09629359890758.