PMID- 9927368
OWN - NLM
STAT- MEDLINE
DCOM- 19990305
LR  - 20151119
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 159
IP  - 2
DP  - 1999 Feb
TI  - Association of HLA class I antigens with diffuse panbronchiolitis in Korean 
      patients.
PG  - 526-9
AB  - Diffuse panbronchiolitis (DPB) is a chronic obstructive pulmonary disease of 
      unknown etiology. Observations of significantly increased frequency of human 
      leukocyte antigen (HLA)-B54 in Japanese patients and occurrence of familial cases 
      suggest possible genetic predisposition to the disease susceptibility. To 
      evaluate the possible association of HLA with the disease in Koreans, we have 
      analyzed 30 patients for HLA class I (A, B, C) and class II (DR) antigens by the 
      serologic and DNA typing methods, respectively. The most significant change in 
      the patients compared to the control subjects was increased frequency of HLA-A11 
      (53.3% versus 17.5%, corrected p [pc] = 1.2 x 10(-)4, odds ratio [OR] = 5.4). In 
      addition, B55 showed significant positive association (16.7% versus 3.5%, pc = 
      0.05, OR = 5.5), and B62 and Cw4 showed rather weak association with the disease. 
      Certain A11-associated haplotypes showed much stronger positive association with 
      the disease, compared to A11 antigen itself. Observations of a strong association 
      of HLA-A11 in Koreans and B54 in Japanese with DPB suggest that the candidate 
      gene(s) responsible for the disease susceptibility is located within the HLA 
      class I region, most probably between HLA-A and HLA-B loci.
FAU - Park, M H
AU  - Park MH
AD  - Department of Clinical Pathology, Seoul National University College of Medicine, 
      Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Korea.parkmhee@plaza.snu.ac.kr
FAU - Kim, Y W
AU  - Kim YW
FAU - Yoon, H I
AU  - Yoon HI
FAU - Yoo, C G
AU  - Yoo CG
FAU - Han, S K
AU  - Han SK
FAU - Shim, Y S
AU  - Shim YS
FAU - Kim, W D
AU  - Kim WD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Biomarkers)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A11 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B54 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Bronchiolitis/genetics/*immunology
MH  - DNA/analysis
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics/immunology
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-A11 Antigen
MH  - HLA-B Antigens/genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Histocompatibility Antigens Class II/genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Japan
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
EDAT- 1999/02/02 00:00
MHDA- 1999/02/02 00:01
CRDT- 1999/02/02 00:00
PHST- 1999/02/02 00:00 [pubmed]
PHST- 1999/02/02 00:01 [medline]
PHST- 1999/02/02 00:00 [entrez]
AID - 10.1164/ajrccm.159.2.9805047 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1999 Feb;159(2):526-9. doi: 
      10.1164/ajrccm.159.2.9805047.