PMID- 9928675
OWN - NLM
STAT- MEDLINE
DCOM- 19990503
LR  - 20121115
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 46
IP  - 1
DP  - 1998 Nov
TI  - Evaluation of the developmental toxicity of methacrylamide and 
      N,N'-methylenebisacrylamide in Swiss mice.
PG  - 124-33
AB  - Timed-pregnant CD-1 outbred albino Swiss mice received either methacrylamide 
      (MAC; 0, 60, 120, or 180 mg/kg/day) or N,N'-methylenebisacrylamide (BAC; 0, 3, 
      10, or 30 mg/kg/day) p.o. in distilled water on gestational days (GD) 6 through 
      17. Maternal clinical status was monitored daily. At termination (GD 17), 
      confirmed-pregnant females (27-30 per group, MAC; 24-25 per group, BAC) were 
      evaluated for clinical status and gestational outcome; live fetuses were examined 
      for external, visceral, and skeletal malformations. For MAC, no treatment-related 
      maternal mortality was observed. Maternal body weight on GD 17, maternal weight 
      gain during treatment and gestation, and corrected maternal weight gain were 
      reduced at the high dose. Relative maternal food and water intake was not 
      adversely affected; neurotoxicity was not observed. Relative maternal liver 
      weight was increased at > or = 120 mg/kg/day; gravid uterine weight was decreased 
      at 180 mg/kg/day. The maternal no-observed adverse effect level (NOAEL) was 60 
      mg/kg/day. The NOAEL for developmental toxicity was also 60 mg/kg/day. At > or = 
      120 mg/kg/day, mean fetal body weight was reduced. At 180 mg/kg/day, increased 
      postimplantation death per litter was observed. Morphological development was not 
      affected. The maternal NOAEL for BAC was 10 mg/kg/day. At 30 mg/kg/day, decreased 
      maternal body weight on GD 17, maternal body weight change during treatment and 
      gestation, corrected maternal body weight, and gravid uterine weight were 
      observed. Relative maternal liver weight increased at 30 mg/kg/day. The 
      developmental NOAEL was 3 mg/kg/day BAC. Mean fetal body weight was reduced at 30 
      mg/kg/day. At > or = 10 mg/kg/day, an increased incidence of fetal variations 
      (extra rib) was observed, although fetal malformation rate was unaffected. MAC 
      and BAC were not teratogenic to Swiss mice at the doses tested. BAC was more 
      potent than MAC in causing adverse maternal and developmental effects.
FAU - George, J D
AU  - George JD
AD  - Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, 
      North Carolina 27709-2194, USA.
FAU - Price, C J
AU  - Price CJ
FAU - Marr, M C
AU  - Marr MC
FAU - Myers, C B
AU  - Myers CB
FAU - Schwetz, B A
AU  - Schwetz BA
FAU - Heindel, J J
AU  - Heindel JJ
LA  - eng
GR  - N01-ES-45061/ES/NIEHS NIH HHS/United States
GR  - N01-ES-95255/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Acrylamides)
RN  - 0 (Teratogens)
RN  - EDK4RIE19C (N,N'-methylenebisacrylamide)
RN  - K67NG89J77 (methacrylamide)
SB  - IM
CIN - Toxicol Sci. 1999 Jul;50(1):152. PMID: 10445764
MH  - Abnormalities, Multiple/chemically induced/pathology/physiopathology
MH  - Acrylamides/*toxicity
MH  - Animals
MH  - Embryo, Mammalian/pathology
MH  - Embryonic and Fetal Development/drug effects
MH  - Female
MH  - Maternal Exposure
MH  - Mice
MH  - No-Observed-Adverse-Effect Level
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Structure-Activity Relationship
MH  - Teratogens/*toxicity
MH  - Weight Gain/drug effects
EDAT- 1999/02/03 00:00
MHDA- 1999/02/03 00:01
CRDT- 1999/02/03 00:00
PHST- 1999/02/03 00:00 [pubmed]
PHST- 1999/02/03 00:01 [medline]
PHST- 1999/02/03 00:00 [entrez]
AID - S1096-6080(98)92506-9 [pii]
AID - 10.1006/toxs.1998.2506 [doi]
PST - ppublish
SO  - Toxicol Sci. 1998 Nov;46(1):124-33. doi: 10.1006/toxs.1998.2506.