PMID- 9933102
OWN - NLM
STAT- MEDLINE
DCOM- 19990216
LR  - 20220410
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 29
IP  - 1
DP  - 1999 Jan
TI  - Leishmania donovani infection initiates T cell-independent chemokine responses, 
      which are subsequently amplified in a T cell-dependent manner.
PG  - 203-14
AB  - Control of Leishmania donovani infection in immunocompetent mice is associated 
      with hepatic inflammation and granuloma formation, both of which are absent in 
      severe combined immunodeficient (scid) mice. In both BALB/c and scid mice, L. 
      donovani infection induced a rapid hepatic accumulation of mRNA encoding 
      macrophage inflammatory protein-1alpha (MIP-(1alpha), monocyte chemoattractant 
      protein-1 (MCP-1) and interferon-gamma inducible protein-10 (gammaIP-10). This 
      response was not preceded by increased IL-4 production in either strain, unlike 
      that reported in other infectious disease models. Interestingly, only gammaIP-10 
      mRNA was maintained at elevated levels throughout the first 7 days of infection, 
      by mechanisms involving CD4+ and CD8+ T cells, and CD4+CD8+ cells not activated 
      in scid mice. By in vivo depletion and reconstitution of scid mice it was 
      demonstrated that T cells regulate the expression of all three chemokines 
      studied, while they themselves only produce gammaIP-10 in appreciable quantities.
FAU - Cotterell, S E
AU  - Cotterell SE
AD  - Department of Infectious and Tropical Diseases, London School of Hygiene and 
      Tropical Medicine, GB. Sara.Cotterell@Ishtm.ac.uk
FAU - Engwerda, C R
AU  - Engwerda CR
FAU - Kaye, P M
AU  - Kaye PM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (RNA, Messenger)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Chemokine CCL2/biosynthesis/genetics
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CXCL10
MH  - Chemokines/*biosynthesis/*genetics
MH  - Chemokines, CXC/biosynthesis/genetics
MH  - Female
MH  - Gene Expression Regulation
MH  - Granuloma/etiology
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-4/biosynthesis/genetics
MH  - Kinetics
MH  - Leishmania donovani/*immunology
MH  - Leishmaniasis, Visceral/*genetics/*immunology
MH  - Liver/immunology
MH  - Liver Diseases/etiology
MH  - Macrophage Inflammatory Proteins/biosynthesis/genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, SCID
MH  - Models, Biological
MH  - RNA, Messenger/genetics/metabolism
MH  - T-Lymphocytes/*immunology
EDAT- 1999/02/05 03:02
MHDA- 2000/06/20 09:00
CRDT- 1999/02/05 03:02
PHST- 1999/02/05 03:02 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/02/05 03:02 [entrez]
AID - 10.1002/(SICI)1521-4141(199901)29:01<203::AID-IMMU203>3.0.CO;2-B [doi]
PST - ppublish
SO  - Eur J Immunol. 1999 Jan;29(1):203-14. doi: 
      10.1002/(SICI)1521-4141(199901)29:01<203::AID-IMMU203>3.0.CO;2-B.