PMID- 993313
OWN - NLM
STAT- MEDLINE
DCOM- 19770129
LR  - 20111117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 43
IP  - 5
DP  - 1976 Nov
TI  - Effects of carbohydrate restriction on the hypoglycemic phase of the glucose 
      tolerance test.
PG  - 1088-93
AB  - The effects of carbohydrate (CHO) restriction on the hypoglycemic phase of the 
      glucose tolerance test were studied in ten normal subjects. The mean nadir plasma 
      glucose was 64 +/- 4 mg/dl (x +/- SEM) for the control test, and 48 +/- 4 mg/dl 
      (P less than 0.01) after 3 days of an isocaloric low CHO diet. Following the low 
      CHO diet, six of ten subjects had a nadir plasma glucose less than 50 mg/dl, and 
      five of these six had mild symptoms of hypoglycemia compared to no biochemical or 
      symptomatic hypoglycemia during the control test. Hormone secretory patterns 
      under the two experimental conditions were measured. CHO restriction produced a 
      significant decrease in early insulin release followed by excessive insulin 
      relative to the control test at 3-4 h of the test. Glucose ingestion produced a 
      depression of plasma, glucagon from fasting levels during the control test, which 
      was impaired following CHO restriction. Plasma growth hormone and cortisol 
      responses were not different under the two experimental conditions. These studies 
      demonstrate that CHO restriction followed by concentrated CHO ingestion produces 
      hypoglycemia in normals. They emphasize the need to consider dietary history in 
      evaluation of hypoglycemia. CHO restriction may provide a useful model for 
      further study of the mechanisms of hypoglycemia.
FAU - Permutt, M A
AU  - Permutt MA
FAU - Delmez, J
AU  - Delmez J
FAU - Stenson, W
AU  - Stenson W
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - *Dietary Carbohydrates/metabolism
MH  - Female
MH  - Glucagon/blood
MH  - *Glucose Tolerance Test
MH  - Humans
MH  - Hypoglycemia/*etiology
MH  - Insulin/blood
MH  - Male
EDAT- 1976/11/01 00:00
MHDA- 1976/11/01 00:01
CRDT- 1976/11/01 00:00
PHST- 1976/11/01 00:00 [pubmed]
PHST- 1976/11/01 00:01 [medline]
PHST- 1976/11/01 00:00 [entrez]
AID - 10.1210/jcem-43-5-1088 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1976 Nov;43(5):1088-93. doi: 10.1210/jcem-43-5-1088.