PMID- 993735
OWN - NLM
STAT- MEDLINE
DCOM- 19770129
LR  - 20070724
IS  - 0340-076X (Print)
IS  - 0340-076X (Linking)
VI  - 14
IP  - 10
DP  - 1976 Oct
TI  - Automation in the hematology laboratory.
PG  - 485-97
AB  - In the routine laboratory for hematology conflicting results may be obtained for 
      the red blood cell parameters with the Coulter Counter Model S. These 
      parameters2) are: mean corpuscular volume (MCV), mean corpuscular hemoglobin 
      (MCH) and mean corpuscular hemoglobin concentration (MCHC). When the values of 
      the MCHC are above 36 g/dl something must be wrong with the blood sample of the 
      patient. One of the reasons can be agglutination e.g. by cold agglutinins. The 
      blood sample should be reanalysed before and after heating for 1 hour at 37 
      degrees C. If the values change: cold agglutinins are present; if no change 
      occurs paraproteins, or other disturbing factors, such as bilirubin or high 
      leucocyte levels, will be found. MCH values may also be high in some cases e.g. 
      if the red blood cells are coated with antibodies (Coombs test positive) or after 
      ingestion of medicines like Azathioprine. These examples show that it is possible 
      in some cases to correlate immunological findings with the red blood cell 
      parameters. In addition to the results with the Coulter Counter Model S, some 
      observations on the Hemalog (Technicon) are also presented.
FAU - De Lange, J A
AU  - De Lange JA
FAU - Rutten, W P
AU  - Rutten WP
FAU - Schmidt, N A
AU  - Schmidt NA
FAU - Eernisse, J G
AU  - Eernisse JG
FAU - Veltkamp, J J
AU  - Veltkamp JJ
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Clin Chem Clin Biochem
JT  - Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur 
      klinische Chemie und klinische Biochemie
JID - 7701860
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Blood Cell Count/*instrumentation
MH  - Blood Platelets
MH  - Diagnostic Errors
MH  - Erythrocyte Count
MH  - Hematocrit
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Leukocyte Count
EDAT- 1976/10/01 00:00
MHDA- 1976/10/01 00:01
CRDT- 1976/10/01 00:00
PHST- 1976/10/01 00:00 [pubmed]
PHST- 1976/10/01 00:01 [medline]
PHST- 1976/10/01 00:00 [entrez]
PST - ppublish
SO  - J Clin Chem Clin Biochem. 1976 Oct;14(10):485-97.