PMID- 9949181
OWN - NLM
STAT- MEDLINE
DCOM- 19990311
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 93
IP  - 4
DP  - 1999 Feb 15
TI  - Cytogenetic profile of lymphoma of follicle mantle lineage: correlation with 
      clinicobiologic features.
PG  - 1372-80
AB  - Conventional chromosome analysis (CCA) and interphase fluorescence in situ 
      hybridization (FISH) was performed in 42 patients with mantle-cell lymphoma 
      (MCL), with BCL1 rearrangement. The t(11;14)(q13;q32) or 11q abnormalities were 
      detected by CCA in 34 cases, 20 of which had additional aberrations. A normal 
      karyotype was observed in 8 cases. Probes detecting the chromosome aberrations 
      that were observed in at least 3 cases by CCA, ie, +12, 13q14 deletion, and 17p 
      deletion, were used for interphase FISH analysis. FISH detected total or partial 
      +12, 13q14 deletion and 17p- in 28.5%, 52.4%, and 26% of the cases, respectively. 
      The presence of these anomalies was not a function of karyotype complexity. Based 
      on the results of CCA/FISH, three groups of increasing karyotype complexity were 
      recognized: group 1, including 11 patients without detectable aberrations in 
      addition to BCL1 rearrangement; group 2, including 14 patients with 1 to 2 
      additional anomalies; and group 3, including 17 patients with three or more 
      additional anomalies. Clinical parameters associated with shorter survival were 
      male sex (P =.006) and primary lymph-node involvement compared with primary bone 
      marrow involvement (P =.015). Trisomy 12 was the only single cytogenetic 
      parameter predictive of a poor prognosis (P =.006) and the best prognostic 
      indicator was the derived measure of karyotype complexity (P <.0001), which 
      maintained statistical significance in multivariate analysis (P<.0001). We 
      arrived at the following conclusions: 13q14 deletion occurs at a high incidence 
      in MCL; 17p deletion and total/partial +12 are relatively frequent events in MCL, 
      the latter aberration being associated with a shorter survival; and the degree of 
      karyotype complexity has a strong impact on prognosis in this neoplasia.
FAU - Cuneo, A
AU  - Cuneo A
AD  - Department of Biomedical Sciences-Hematology Section, University of Ferrara, 
      Italy. sse@dns.unife.it
FAU - Bigoni, R
AU  - Bigoni R
FAU - Rigolin, G M
AU  - Rigolin GM
FAU - Roberti, M G
AU  - Roberti MG
FAU - Bardi, A
AU  - Bardi A
FAU - Piva, N
AU  - Piva N
FAU - Milani, R
AU  - Milani R
FAU - Bullrich, F
AU  - Bullrich F
FAU - Veronese, M L
AU  - Veronese ML
FAU - Croce, C
AU  - Croce C
FAU - Birg, F
AU  - Birg F
FAU - Dohner, H
AU  - Dohner H
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Castoldi, G
AU  - Castoldi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Lineage/*genetics
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 14
MH  - Cyclin D1/genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Lymphoma/*genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 1999/02/09 00:00
MHDA- 1999/02/09 00:01
CRDT- 1999/02/09 00:00
PHST- 1999/02/09 00:00 [pubmed]
PHST- 1999/02/09 00:01 [medline]
PHST- 1999/02/09 00:00 [entrez]
AID - S0006-4971(20)48776-2 [pii]
PST - ppublish
SO  - Blood. 1999 Feb 15;93(4):1372-80.