PMID- 9949877
OWN - NLM
STAT- MEDLINE
DCOM- 19990223
LR  - 20191102
IS  - 1023-294X (Print)
IS  - 1023-294X (Linking)
VI  - 86
DP  - 1998
TI  - Immunochemical approaches to studies of CYP1A localization and induction by 
      xenobiotics in fish.
PG  - 165-202
AB  - There is an increasing understanding that polynuclear aromatic hydrocarbons 
      (PAHs) and organochlorine compounds (like polychlorinated biphenyls (PCBs), 
      certain pesticides and dioxins) in the aquatic environment may lead to 
      physiological and pathological effects such as immunological disturbances, 
      effects on reproduction and development, and even neoplasms. Exposure to 
      pollutants may have consequences at all levels in the biological organization, 
      from the cellular level over effects on the individual organism, population, to 
      the entire ecosystem. The cytochrome P450 system (CYP or P450) has an essential 
      function in the biotransformation of endogenous and exogenous compounds. The fact 
      that many different environmental pollutants induce de novo synthesis of 
      cytochrome P450 1A (CYP1A) proteins in fish, gives these enzymes an interesting 
      position in aquatic toxicology. Many investigations concerning the CYP1A system 
      in fish have been performed over the last two decades, demonstrating its 
      usefulness as a biomarker for aquatic pollution. A general overview of the 
      biochemical and toxicological aspects concerning the cytochrome P450 system will 
      be given here, followed by a more detailed description of CYP1A induction 
      responses in fish. Ecotoxicological consequences of CYP1A induction and the use 
      of immunochemical techniques for CYP1A detection as a biomarker in environmental 
      monitoring will be discussed.
FAU - Goksoyr, A
AU  - Goksoyr A
AD  - Department of Molecular Biology, University of Bergen, Norway.
FAU - Husoy, A M
AU  - Husoy AM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - EXS
JT  - EXS
JID - 9204529
RN  - 0 (Oxazines)
RN  - 0 (Xenobiotics)
RN  - 5725-91-7 (ethoxyresorufin)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
SB  - IM
MH  - Animals
MH  - Biotransformation
MH  - Cytochrome P-450 CYP1A1/*analysis/*biosynthesis/genetics
MH  - Cytochrome P-450 CYP1A2/analysis/biosynthesis/genetics
MH  - Enzyme Induction
MH  - Fishes/*metabolism
MH  - Oxazines/metabolism
MH  - Xenobiotics/pharmacokinetics/*pharmacology
RF  - 207
EDAT- 1999/02/09 00:00
MHDA- 1999/02/09 00:01
CRDT- 1999/02/09 00:00
PHST- 1999/02/09 00:00 [pubmed]
PHST- 1999/02/09 00:01 [medline]
PHST- 1999/02/09 00:00 [entrez]
AID - 10.1007/978-3-0348-8853-0_5 [doi]
PST - ppublish
SO  - EXS. 1998;86:165-202. doi: 10.1007/978-3-0348-8853-0_5.