PMID- 9952008
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190915
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 45
IP  - 1
DP  - 1999 Jan-Feb
TI  - Evaluation of a physiologic pulsatile pump system for neonate-infant 
      cardiopulmonary bypass support.
PG  - 53-8
AB  - An alternate physiologic pulsatile pump (PPP) system was designed and evaluated 
      to produce sufficient pulsatility during neonate-infant open heart surgery. This 
      hydraulically driven pump system has a unique "dual" pumping chamber mechanism. 
      The first chamber is placed between the venous reservoir and oxygenator and the 
      second chamber between the oxygenator and patient. Each chamber has two 
      unidirectional tricuspid valves. Stroke volume (0.2-10 ml), upstroke rise time 
      (10-350 msec), and pump rate (2-250 beats per minute [bpm]) can be adjusted 
      independently to produce adequate pulsatility. This system has been tested in 
      3-kg piglets (n = 6), with a pump flow of 150 ml/kg/min, a pump rate of 150 bpm, 
      and a pump ejection time of 110 msec. After initiation of cardiopulmonary bypass 
      (CPB), all animals were subjected to 25 minutes of hypothermia to reduce the 
      rectal temperatures to 18 degrees C, 60 minutes of deep hypothermic circulatory 
      arrest (DHCA), then 10 minutes of cold perfusion with a full pump flow, and 40 
      minutes of rewarming. During CPB, mean arterial pressures were kept at less than 
      50 mm Hg. Mean extracorporeal circuit pressure (ECCP), the pressure drop of a 10 
      French aortic cannula, and the pulse pressure were 67+/-9, 21+/-6, and 16+/-2 mm 
      Hg, respectively. All values are represented as mean+/-SD. No regurgitation or 
      abnormal hemolysis has been detected during these experiments. The oxygenator had 
      no damping effect on the quality of the pulsatility because of the dual chamber 
      pumping mechanism. The ECCP was also significantly lower than any other known 
      pulsatile system. We conclude that this system, with a 10 French aortic cannula 
      and arterial filter, produces adequate pulsatility in 3 kg piglets.
FAU - Undar, A
AU  - Undar A
AD  - Congenital Heart Surgery Service, Texas Children's Hospital, Houston 77030-2399, 
      USA.
FAU - Masai, T
AU  - Masai T
FAU - Inman, R
AU  - Inman R
FAU - Beyer, E A
AU  - Beyer EA
FAU - Mueller, M A
AU  - Mueller MA
FAU - McGarry, M C
AU  - McGarry MC
FAU - Frazier, O H
AU  - Frazier OH
FAU - Fraser, C D Jr
AU  - Fraser CD Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Cardiopulmonary Bypass/*instrumentation
MH  - Disease Models, Animal
MH  - Equipment Design
MH  - Femoral Artery/physiopathology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Monitoring, Intraoperative
MH  - Pulsatile Flow
MH  - Pulse
MH  - Swine
EDAT- 1999/02/10 03:02
MHDA- 2001/03/28 10:01
CRDT- 1999/02/10 03:02
PHST- 1999/02/10 03:02 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/02/10 03:02 [entrez]
AID - 10.1097/00002480-199901000-00013 [doi]
PST - ppublish
SO  - ASAIO J. 1999 Jan-Feb;45(1):53-8. doi: 10.1097/00002480-199901000-00013.