PMID- 9952034
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 141
IP  - 2
DP  - 1999 Jan
TI  - Ganglioside GM1 attenuates scopolamine-induced amnesia in rats and mice.
PG  - 111-7
AB  - Some experimental evidence suggests that the beneficial effects of 
      monosialoganglioside GM1 on learning and memory could be related to an improving 
      effect in central cholinergic function. The present study investigates the 
      effects of GM1 on the memory impairment induced by scopolamine in rats or mice 
      tested in passive (PA) and discriminative avoidance (DA) tasks, respectively. 
      Wistar EPM-1 male rats and Swiss EPM-M1 male mice were treated daily IP with 50 
      mg/kg GM1 or saline for 7 or 14 days, respectively. Twenty-four hours after the 
      last injection, GM1-treated animals received 1 mg/kg scopolamine (GM1-SCO) and 
      saline-treated animals received 1 mg/kg scopolamine (SAL-SCO) or saline (SAL-SAL) 
      IP. Twenty minutes later, the animals were submitted to PA or DA conditioning, 
      and tests were performed 24 h later. The latency in entering the dark chamber of 
      the PA apparatus (LD) presented by SAL-SCO rats was significantly decreased when 
      compared to that presented by SAL-SAL animals. GM1-SCO animals showed an 
      increased LD when compared to SAL-SCO animals and were not significantly 
      different from SAL-SAL rats. GM1-SCO and SAL-SAL (but not SAL-SCO) mice spent 
      significantly less time in the aversive enclosed arm of the discriminative 
      avoidance apparatus when compared to the time spent in the non-aversive enclosed 
      arm. The results are consistent with the interpretation that GM1 attenuates 
      scopolamine-induced amnesia. Although not eliminating the participation of other 
      transmitter systems, the present study indicates a possible role of central 
      cholinergic transmission in the action of this compound on learning and memory.
FAU - Silva, R H
AU  - Silva RH
AD  - Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal 
      de Sao Pualo, UNIFESP, SP, Brazil.
FAU - Felicio, L F
AU  - Felicio LF
FAU - Frussa-Filho, R
AU  - Frussa-Filho R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 37758-47-7 (G(M1) Ganglioside)
RN  - DL48G20X8X (Scopolamine)
SB  - IM
MH  - Amnesia/chemically induced/*prevention & control
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Discrimination Learning/drug effects
MH  - G(M1) Ganglioside/*pharmacology
MH  - Learning/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/*drug effects
MH  - Mice
MH  - Rats
MH  - Rats, Wistar
MH  - Scopolamine
EDAT- 1999/02/10 00:00
MHDA- 1999/02/10 00:01
CRDT- 1999/02/10 00:00
PHST- 1999/02/10 00:00 [pubmed]
PHST- 1999/02/10 00:01 [medline]
PHST- 1999/02/10 00:00 [entrez]
AID - 10.1007/s002130050814 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1999 Jan;141(2):111-7. doi: 10.1007/s002130050814.